IT is a picture of the fundus. I am not sure about what is this indicative of and what landmarks should I take into consideration. I have acquired a lot of such images but I am not able to interpret them.
Indeed - it is the holangiotic fundus of an albino rat or mouse. The nerve head and retinal vessels look normal - what are the clinical findings of the animal - is there any change in vision or behaviour?
Yes you are right. It is not human fundus. It is a rodent fundus. That is why I need help in the first place. Had it been a human fundus, it would have been quite easy a job.
Indeed - it is the holangiotic fundus of an albino rat or mouse. The nerve head and retinal vessels look normal - what are the clinical findings of the animal - is there any change in vision or behaviour?
Dear Prof. Williams,
Thank you for your answer. I think we have already met in the 2016 Cambridge Ophthalmological Symposium in St. John's College, Cambridge. I remember your talk of regenerative aspects. I could never forget the beautiful music you played.
Now coming to the "Fundus Question": This is a picture of a healthy Wistar rat which happened to be in the control group of our experiment. In 2014, we propounded the Brain Diabetes Theory of Glaucoma and happened to publish a series of papers on the subject. It was important to conduct some animal experiments to validate our hypothesis. A series of experiments were, therefore, effectuated. Our results are in complete agreement to what we have proposed. The only issue is that I am not able to interpret the fundus images. I was in London recently and visited Moorfield's Eye hospital to seek help, but I did not find satisfactory interpreter in Moorfield's as well as in the Institute of Ophthalmology adjacent to it. Then I was in Korea Brain Research Institute for some time where I approached the experts. I again had to cut a sorry figure. I had a lecture in Hong KOng and Singapore recently, I tried to get help in the SERI and HKEH but to no avail.
Since I am joining New York University School of Medicine in June this year, I want to communicate and publish the results before I move.
This is how I landed here. I have many pictures of both the control and intervention groups. My gene expression, microarray, immunohistochemistry, cell biology, etc are all done. I am left with this portion. Since I am not a veterinarian and have no experience in animal model fundus, I am unable to interpret the results.
What do you suggest?
I'd be happy to help if you wanted to send me the pictures to [email protected]. All the best, David
I don't think the white areas are cotton wool spots, rather just areas of white sclera visible. If they were exudates or oedema this would suggest that the fundus was abnormal - I don't think it is.
I wonder, what type of intervention did you perform?
The picture seems slightly blued due to defocus and difficult to interpret exactly.
Although; two of retinal hemorrhages are seen upper part of the picture; like Roth's spots. I added a normal rat fundus picture, it may be useful.
You do have to be careful that the apparently widely varied appearances of these two fundus images may be because the two rats are of different strains - they can have markedly different degrees of retinal pigment epithelial and choroidal pigmentation.
Dear Muneeb, We corresponded about this rat fundus about a year ago and I wondered how your researches are going - what happened to the animals and the project in which they were involved? Yours ever, David
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