It depends, DNA-based nanostructures could be targeted to cell surfaces via antibody–antigen interactions, and their cellular uptake can be stimulated by modification with receptor ligands, while membrane-embedded DNA nanostructures are expected to find application in diverse areas ranging from basic biological research over nanotechnology to synthetic biology. Despite the different chemical nature of DNA compared to proteins, its high binding fidelity, sequence specificity, directionality of hybridization, and ability to form asymmetric interactions with its complement triggered the use of DNA-lipid hybrid assemblies as powerful tools to mimic membrane processes.

please review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850321/

Hi Tarek, thanks for your answer.