The technique used was solvent evaporation and the solid product shows presence of drug melt with cocrystals in DSC.
Thank you sir, i have tried PXRD but the pattern obtained is diffused that is for the whole powder system. I tried DSC and confirmed the presence of cocrystals. For solubility, the system shows absorption maxima at a different wavelength thus making separation inevitable for detection.
You could also try IR to determine if there is some interaction of the expected synthon. If there is some interaction (even incomplete conversion) you should be able to see it in the IR spectra. The attached reference uses IR as one of the characterisation techniques
I hope this helps.
Article Co-Crystals of Caffeine and Hydroxy-2-naphthoic Acids: Unusu...
Thank you sir, i observed the difference in Infrared. The infrared also indicated change in the drug polymorphic form.
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