I have tried several different differentiation protocols and wildtype progenitors differentiate whilst AD derived progenitors fail. I have found some literature to suggest this also occurs in mice. (J Neurosci Res. 2010 Aug 1;88(10):2103-17.
Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice. Demars M, Hu YS, Gadadhar A, Lazarov O.) Anyone else experienced this phenomenon? Makes studying the pathology in these cells very difficult when you cant generate any neurons in-vitro. Are stem cells really going to help us study basic mechanisms of familial AD.
I am also interested in the answer for Vanessa's question. But which familial AD are your cells Vanessa? APP or Psen?
I am sending to your attention updated information on the matter.
Telomere Length Shortening and Alzheimer Disease—A Mendelian Randomization StudyYiqiang Zhan, MD1; Ci Song, PhD1; Robert Karlsson, PhD1; Annika Tillander, PhD1; Chandra A. Reynolds, PhD2; Nancy L. Pedersen, PhD1; Sara Hägg, PhD1
[+-] Author Affiliations 1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
2Department of Psychology, University of California, Riverside
JAMA Neurol. 2015;72(10):1202-1203. doi:10.1001/jamaneurol.2015.1513.
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