Cordycepin which is very similar to adenosine but lacks a 3′-hydroxyl group, can be erroneously
identified and replaces nucleosides and interrupts the polyadenylation of mRNA, causing dysfunction in pathogen cellular mechanism and inhibiting the growth of pests and pathogenic microorganisms, virus. Previous work demonstrated that cordycepin inhibited the growth of pathogenic, microorganisms, including Bacillus subtilis, adenovirus, murine leukovirus, murine sarcoma virus, Newcastle disease virus, human poliovirus, tobacco mosaic virus, vaccinia virus, hepatitis C virus, Clostridium paraputrificum and Clostridium perfringens and Candida.
No it will not affect host cell in moderate doses, as host cell nucleus is intact and viral dna /rna is membrane free on entering host cell , it will take up whatever available to it for replication. Cordycepin possess structural similarity with adenosine except that, it lacks a 3′ hydroxyl group in its ribose moiety and hence it served as a poly(A) polymerase inhibitor, induced shortening of poly(A) tails, destabilization of mRNAs, inhibits purine biosynthesis and premature termination of protein synthesis. It is known that during replication in nCOVID-19, full-length (-) RNA copies of the genome are synthesized leading to all viral proteins and if cordycepin can destabilize nCOVID-19 RNA then it may be a breakthrough in terms of inhibition of viral replication and multiplication in the host.
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