Seizures represent hypersynchronous phenomenon and manifest a gradual process leading the brain to develop epilepsy. Whereas, diagnosing epilepsy and preventing seizures require the knowledge of epileptogenesis that relates to one common feature- hyperexcitability.
We know that axonal sprouting, cell death, reorganization of neural networks, neurogenesis, and a variety of other changes occur during epileptogenesis. However, there are a variety of pathophysiological factors that can cause hyperexcitability.
What in your suggestion are the most important factors that can cause epileptogenesis in perspective to neural reorganization. The second part of the question is: how epileptogenesis can be reverted?
Dear Zahir Hussain
I am interested in your question, which implies:
- First, to know the triggers of epileptic seizures and
- Secondly, to be able to promote protective factors that have the virtue of increasing the threshold of neuronal excitability or blocking neurological pathways or receptors, in order to avoid the release of neurotransmitters (or diminish their synthesis) that are the last ones Instance, stimulate the excitability of a group of neurons.
Therefore, in the knowledge of the Pathophysiology of Epilepsy, we must consider the following:
- That crises do not occur suddenly from a site of organic injury, functional, or biochemical alteration.
- Neither is the response of a single neuron, it is required that the phenomenon of depolarization and repolarization of the membrane of several nearby neurons and in contact, propagate in wave form or from the center to the periphery; Until a large group of them produces an epileptic discharge within the group of said neurons if there is synchrony, but asynchrony with respect to the other neurons of the brain.
The following paragraph expresses almost the same terms and arguments as before:
- The initial idea that minimizes its pathophysiology to a series of depolarizations and successive repolarizations that produce sudden episodes of organized electrical activity, but at the same time lacking synchrony in relation to the rest of the functions of the central nervous system (CNS); That is, in this nosological entity rhythmic, but asynchronous discharges are generated.
Enlarged information that appears in the Bulletin of the National Academy of Medicine of Mexico, which can be accessed by following the link:
- http://www.medigraphic.com/pdfs/facmed/un-2016/un165g.pd
The above mentioned only as a preamble to continue and enrich this network of discussion and argumentation.
regards
Jose Luis
Estimado Zahir Hussain
Me interesa su pregunta, la cual implica:
- En primer lugar, conocer los factores desencadenantes de las crisis epilépticas y
- En segundo lugar, estar en posibilidad de promover los factores protectores que tengan la virtud de aumentar el umbral de excitabilidad neuronal o bloquear vías neurológicas o receptores, para así evitar, la liberación de neurotransmisores (o disminuir su síntesis) que son los que en última instancia, estimulan la excitabilidad de un grupo de neuronas.
Por tanto, en el conocimiento de la Fisiopatología de la Epilepsia hay que considerar lo siguiente:
- Que las crisis no se presentan en forma súbita desde un sitio de lesión orgánica, funcional, o de alteración bioquímica.
- Tampoco es la respuesta de una sola neurona, se requiere que el fenómeno de despolarización y repolarización de la membrana de varias neuronas cercanas y en contacto, se vaya propagando en forma ondulatoria o del centro a la periferia; hasta que un grupo grande de ellas produzca una descarga epiléptica que dentro del grupo de dichas neuronas si hay sincronía, pero asincronía respecto de las demás neuronas del cerebro.
El siguiente párrafo expresa casi con los mismos términos y argumentos lo antes dicho:
- La idea inicial que minimiza su fisiopatología a una serie de despolarizaciones y repolarizaciones sucesivas que producen episodios súbitos de actividad eléctrica organizada, pero al mismo tiempo carente de sincronía con relación al resto de las funciones que desempeña el sistema nervioso central (SNC); es decir, en esta entidad nosológica se generan descargas rítmicas, pero asincrónicas.
Información ampliada que aparece en el Boletín de la Academia Nacional de Medicina de México, a la cual se puede acceder siguiendo el siguiente vínculo:
- http://www.medigraphic.com/pdfs/facmed/un-2016/un165g.pd
Lo antes mencionado, sólo como preámbulo para continuar y enriquecer esta red de discusión y argumentación.
Saludos
José Luis
Dear Jose Luis
Thank you for describing in detail about the most important factors that can cause epileptogenesis in perspective to neural reorganization; and how epileptogenesis can be reverted?
Many thanks and Best Regards
Zahir
Epiptogenesis is related to the occurrence at the periphery of a damage of picnotic, hyperchrome neurons. They show an exagerated spontaneous or evoked excitability.
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