Hiba Saleem

Although local compression and tension occur during sonication, it does not crush iron particles. Mills do this, mainly dispersing ceramics. Iron has plastic properties. Sonication destroys water and chitosan. Therefore, sonication will not help you. Chitosan is desorbed from iron particles and dissolved in water.

Yuri Mirgorod , I think that Hiba Saleem want to make iron nanoparticles by ultrasonic and then will deposit of chitosan, no? I have also greate interest to regime of deposite of iron nanoparticle by ultrasonic.

Dear Heeba,

I think you need to consider important parameters and do the statistical analysis using ANOVA later on.

Size and surface properties of iron oxide nanoparticles are the two important factors which could dramatically affect the nanoparticle efficiency as well as their stability. To optimize the size of nanoparticles, the effect of two experimental parameters on size it necessities’ the factors to be considered are chitosan molecular weight and chitosan-to-tripolyphosphate concentration ratio.

Size and polydispersity of particles first need to be determined by a Nano Particle Analyzer at room temperature with a perpendicular scattering angle of 90°. The analysis of the surface and shape characteristics of the nanoparticles can be determined using a scanning electron microscope after coating. Two parameters are the most significant effect on the size of nanoparticles. The levels could be selected based on knowledge that acquired from initial experimental trials. These two factors, at three levels, face-centered cube central composite response surface design can be used for testing the robustness of the method. Statistical analysis can be performed on range scaled factor values of [−1, +1] with SPSS software. Use regression analysis if necessary. Use Intercept, coefficients, mean effects, and statistics of the predictive model obtained for the increased size of iron oxide nanoparticles. Use ANOVA, to identify the largest effect on size increasing during coating process of nanoparticles with interaction term between the main factors with p value and mean effect(this all you know using ANOVA if you are familiar).

Hope it work out for you.

Ashish