Does someone have any experience with Cu-catalyzed Azide Alkyne Click Hydrogels, used for any biomedical application? After fabrication of hydrogels and removal of copper,, we do have copper present in trace amounts. Does this amount should of any concern? Secondly, Can somebody tell about the amount being allowed by FDA (Elemental impurities allowed)?
Maybe you could try some Cu-free click variations?
http://www.sigmaaldrich.com/technical-documents/articles/chemistry/copper-free-click-chemistry.html#ref
Thank you for your answer. Yes, there are copper free synthetic procedures but I am just wondering about CuACC click procedures. About how will it act after copper being removed from product. I am more concerned about its interaction with cell viability?
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