Hello,
I have patient who took SSRIs for a short period ( Prozac, Cipram) for anxiety. But He got chronic insomnia now for at least 10 years now. Do you know why He got this side effect?
Best regards,
Dear Yahia,
Check this link out how to cope with insomnia caused by the above mentioned medications:
http://www.mayoclinic.org/diseases-conditions/depression/in-depth/antidepressants/art-20049305
Insomnia and somnolence associated with second-generation antidepressants during the treatment of major depression: A meta-analysis.
doi: http://dx.doi.org/10.1097/JCP.0000000000000329
By Alberti, Siegfried; Chiesa, Alberto; Andrisano, Costanza; Serretti, Alessandro
Journal of Clinical Psychopharmacology, Vol 35(3), Jun 2015, 296-303.
Background: Sleep reduction or enhancement is frequently observed with second-generation antidepressant treatments, and they can be beneficial or harmful depending on the symptom profile of each subject. Nevertheless, relatively little attention has been given so far to rank those effects across compounds. The aim of this meta-analysis is to provide quantitative data about short-term rates of insomnia and somnolence associated with 14 second-generation antidepressants during the treatment of major depression. Methods: A literature search and a search of unpublished documents were performed. Eligible studies focusing on MD patients treated with second-generation antidepressants were entered in the analysis. Our primary outcome measures were insomnia and somnolence rates induced by antidepressants as compared with those associated with placebo. Sensitivity analyses were carried out as well. Results: Ten second-generation antidepressants showed higher rates of insomnia than placebo. The highest incidence was found for bupropion and desvenlafaxine. Agomelatine was the only antidepressant with a lower likelihood of inducing insomnia than placebo. Eleven antidepressants were associated with higher rates of somnolence than placebo. Fluvoxamine and mirtazapine showed the highest frequency of somnolence. Bupropion induced somnolence to a lower extent than placebo. Sensitivity analyses showed a degree of variation of those findings. Discussion: Antidepressants are associated with different insomnia and somnolence rates, mainly depending on their mechanisms of action. Despite some limitations, we underscore that the treatment-emergent insomnia and/or somnolence are frequent, and they could be used in clinical practice to face the specific needs of each patient. (PsycINFO Database Record (c) 2015 APA, all rights reserved)
Thank you a lot dear Beatrice and Hendrika for your input.
But what is the mechanism by which antidepressants cause chronic insomnia? This patient has insomnia now for at least 10 years since he took SSRI?
- Badges
- Science topic
- Similar topics
- Chemistry
- Pharmacology
- Medical Pharmacology