Hi all,
We are planning to systemically deliver a synthetic pharmacological compound in rats. When looking for specific dosage and administration protocols, we only found studies with mice. Although they provide an outstanding characterization of the compound (even with in vitro pharmacodynamics and pharmacokinetics), the fact that they were tested on mice is problematic.
Should we get a rough idea of the doses range from converting the provided doses from mouse to rat (calculations based on body surface - for rats it would be ~1/2 the mice dose) or it is not accurate enough?
Of course, the ideal thing is to carry out some pilots, but we need a starting point.
Thanks!
Dear Santiago Mora,
See table on page 10 document below, should be useful for you. Its FDA guidance from 2005. Using that document you can find common denominator between rats and mice based on general allometrical rules and scaling.
Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers
https://www.fda.gov/media/72309/download
Best regards
Tomasz
Hi Santiago.
I recommend you to use rat body parameters to built your own doses scale.
Best wishes.
Lauro
Dear Tomasz and Lauro,
Thank you very much for your useful tips. I'll take them into account.
Best.
use the OECD guidelines to study the toxicity of compounds on rats. then you can decide the accurate dose.
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