MDA-MB-231 which is a triple negative BC cell line showed significant cell cycle arrest at the S phase and also at the G2/M phase. On the other hand, MCF-7 which is an ER-positive BC cell line showed cell cycle arrest only at the G2/M stage after having the same FEC treatment.
Why MCF-7 cells are escaping the S phase arrest? One reason could be the ERα protein, which accelerates the passage of MCF-7 cells through the S-to-G2 phase transition by upregulating ERα target genes such as cyclin, and cyclin-dependent kinases (Cdks). ERα protein also enhances the expression of cyclin D1 and cyclin E to regulate proliferation and cell cycle progression.
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