Mr.X,is 41 yrs/male, known T2DM.,and on insulin and OAD.in his blood investigation,his Triglycerides levels are vary and those are,like:(nmol/l):3.4 ,23,13,35,30,6.1,9,32,50,2.5 .done on every three months intervals.initially started with rosuvastatin and then changed to fenofibrate,when it was 32.
diagnosed as mixed lipidemia.
my question is,
1.intake of carb,giving these fluctuations when pt.is on medications?
(or)
2.Hepatic lipogenesis largely enhanced in diabetic patients.Which mechanism control the hepatic lipogenesis
and
3.what is the fractional synthetic rate (FSR)to TG.
Just a guess: TG consumptions before analysis: Pizza, cheese, etc. In the case of feasts, the usual "no food period" before blood collection might not be long enough.
Fluctuation of glycemic control can lead to this kind of situation.
Lipoprotein Lipase control the metabolism of TG and LPL depend on insulinemia.
The most likely reasons are :
1. Non - compliance with diet ( eats everything)
2. Excessive alcohol consumption ( beer?)
3. Non - compliance with prescribed medications
4. All of the above + progressive weight gain with growing insulin resistance
Diabetic dyslipemia is quite distinct to other dyslipemias (seee Amigo et al Scientific Reports 6: 19249), for example HDL particles are non functional and have more surface lipids that healthy HDL particles.
dear all, thanks for your answers n really appreciated and am still expecting what kind of metabolic activity for these fluctuations.
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