Migraines and neuralgia are not typical pain disorders, since they originate in cranial nerves and tend to show no response to traditional painkillers. And because of this, CBD may be of benefit, though as a vasodilator (if I am not mistaken), I am skeptical. In any case, when it comes to migraines, it seems that short of triptans, surgery, and maybe anticonvulsants, patients need to try anything.

That said. In terms of CBD and cannabinoids for chronic pain:

It's a fad. It's also a tragic bit of bandwagon science influenced by socio-political trends. By this I mean mainly the recent reflexive and manic reversal of opinion regarding a previously demonized class of drugs (cannabis derivatives) as a safe and efficacious alternative to a newly demonized class of drugs (opiates).

I am sure others who comment will inundate you with papers supposedly showing the incredible efficacy of CBD for pain (in humans and animals), articles showing CBD's various relationships with other neuromodulator systems, and studies indicating its superiority to alternative agents in even severe cases.

I don't buy it. The endocannabinoid system is limited in its neural scope and role and there is no indication, in my opinion, that agents modulating this system will meet the needs of those suffering chronic pain.

I hope I'm wrong, and I truly mean no disrespect to most researchers working in the field. However, I would ask a question to those that gush about the cannabinoid panacea... if YOU fell off a roof or were in a car accident and ended up with chronic debilitating pain, do you honestly think that a CB-acting agent would provide satisfactory pain relief???

I ask those researchers to contemplate the above scenario before making rash and irresponsible claims based on abstractions and small-scale experiments. These claims form public opinion and policy.

Hill, K. P., Palastro, M. D., Johnson, B., & Ditre, J. W. (2017). Cannabis and pain: a clinical review. Cannabis and cannabinoid research, 2(1), 96-104.

Please take a look at this useful RG useful link.

Article Effect of cannabis use in people with chronic non-cancer pai...

In my original response, I had predicted:

"I am sure others who comment will inundate you with papers supposedly showing the incredible efficacy of CBD for pain (in humans and animals), articles showing CBD's various relationships with other neuromodulator systems, and studies indicating its superiority to alternative agents in even severe cases."

Indeed, two other researchers have since responded with article links, though without additional comment.

It worth reminding the above two commenters, and the applied pharmacology community, that CBD and THC appear to have fundamentally different, and even opposing, actions, so the posted articles, according to their titles, conflate the two molecular pathways.

Of equal importance, in my original response, I posed a somewhat provocative question:

"... I would ask a question to those that gush about the cannabinoid panacea... if YOU fell off a roof or were in a car accident and ended up with chronic debilitating pain, do you honestly think that a CB-acting agent would provide satisfactory pain relief???

I ask those researchers to contemplate the above scenario before making rash and irresponsible claims based on abstractions and small-scale experiments. These claims form public opinion and policy."

Again, I respectfully ask those that commented to reply to the above question, since this is of the utmost importance in communicating the honest merits, drawbacks, and probable hype that needs to be addressed when proposing alternative treatments to proven painkiller agents.

CBD may be of benefit for some psychological symptoms like nervousness but it surely van not be considered as a independent treatment. Furthermore, the effects of different CBD oil differs from each

other

THC is far more efficient for pain management

CBD works in matter of hours, ( appr 45 min @)

THC in matter of minutes