As part of my cancer cell bio class, I have to expand on past research and come up with experiments to test a hypothesis. In class we discussed BCL-2 (BCL-xL) and Bax, and how their interaction is argued, so I thought this would be a good topic to expand on.
I have found papers discussing the rheostat theory, and retrotranslocation of Bax that sound very interesting, but I am still having a hard time of building on the current research and coming up with my own hypothesis/experiments to test this.
Does anybody have any ideas/knowledge on current research in this area they could share with me? Current papers that lay a path for future research would be nice, but also maybe just some ideas. Thank you!
or in other words, what studies could I do to test the interaction between Bax/Bak in a normal and cancerous cell
I have anti cancer papers here discussing the relationship of Bax and Bcl 2. you can read them and then follow up more tests from there.
You can see the following papers:
http://www.ncbi.nlm.nih.gov/pubmed/20584903
http://www.ncbi.nlm.nih.gov/pubmed/16023593
http://www.ncbi.nlm.nih.gov/pubmed/23064052
http://www.ncbi.nlm.nih.gov/pubmed/24083449
Based on my recent study, double knockout of Bax-Bak in cancer cells allows the cancer resistant to many chemotherapeutic agents from 5 fold to more than hundreds fold.
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