Hello everyone,
I am interested in targeting cell-type specific gap junctions and was wondering what my options are beyond global pharmacological blockade (anything more reliable than CBX?).
1) Are there specific pharmacological tools to increase the conductivity of GJs, e.g. adenylyl cyclase activators?
2) Is it possible (or has it already been demonstrated) to target GJs using DREADD? I was primarily thinking of Gi-based DREADD to uncouple specific networks. I couldn't find any literature on the topic and was wondering whether it is at all possible.
All the best,
Michael
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