I gone through that research article earlier also.
Their i noticed that they are using Sulfosalicyclic acid as a model drug in PVA hydrogel crosslinked with Glutaraldehyde and it is not reported that Sulfosalicyclic acid acts as a crosslinking agent.
I agree with you sir, as per chemistry of cross linking and the nature of Sulfosalicyclic acid it will easily cross links with PVA and gives good stability too.(i tryed it in my lab)
But i not found any right literature reporting cross linked PVA with Sulfosalicyclic acid, why? is people not worked on this?, or i am not finding that article? or any other science or chemistry that i couldn't understand upto now? it made me bit curious!. So, i posted this question just to confirm it.
5-sulfosalicylic acid CANNOT act as crosslinker for the following reasons:
- COOH and SO3H can only bind as acid groups with basic molecules.
- OH the hydroxyl group can be transformed into an ester group (R-OH → R-OCOCH3). For details see aspirin synthesis.
Can we use 5-Sulfosalicylic acid as a crosslinker for PVA? - ResearchGate. Available from: https://www.researchgate.net/post/Can_we_use_5-Sulfosalicylic_acid_as_a_crosslinker_for_PVA [accessed Feb 20, 2017].
It seems that you don ´t understand that your 5 - sulfosalicylic acid HAS NO GROUPS able to bind covalently when you mix PVA and Your molecule. Only after chemical transformation of these groups is a crosslinking possible.