I have used Composite Design (CCD) of Response Surface Methodology (RSM) in one of my set of experiments. When I enter lower and higher factor values, -alpha and + alpha are automatically generated and some of the alpha values are out of range (for example time is negative in numbers). When I go to the CCD table, I could not able to enter some response values due to the impossible factor values of that run. So can I proceed with the missing data for the next steps such as ANOVA? Please help me

Thank you in advance.

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