Hi,

In certain medical applications like cell therapy, controlled drug delivery etc., it is usually prerequisite that hydrogel should be biodegradable. Biodegradable hydrogel hydrogels are degradable compare to non-degradable hydrogels. Among biodegradable hydrogels few degrade faster than others. The rate of degradation of the hydrogels can be controlled by different parameters like material type, preparation method, molecular weight of the polymers along hydrostatically unstable group and cross linking density.

·         Higher the cross linking density in the hydrogel lower the degradation rate

·         Method of preparation: Usually physical hydrogels degrade faster than chemically prepared hydrogels  (common trend may be few exception)

 How rate of degradation of hydrogels is beneficial?

  It depends on the end application, I will try to illustrate this with simple examples, for cell cultivation biodegradable hydrogels usually act as a temporary extracellular matrix (ECM) until replace by a neo-tissue. So for this kind of application hydrogel degradation rate should be related to the formation of neo-tissues. If neo tissue formed in one week (suppose) than one don’t want to use biodegradable hydrogels with the degradation rate of one year. So in such case faster degradation rate is advantageous.

For drug delivery applications: Usually drug release can be controlled in different ways like osmosis, degradation of matrix (hydrogel) etc.  Advantage of using biodegradation (again rate of degradation is important ) for controlled drug release is that one don’t need to follow other procedure to remove the drug device from the site of action once drug delivery action is completed.

I have tried to answer and I am hoping it will helpful to you.

Regards

Beenish

Although i am not sure of your intended area of use, biodegradable hydrogels could be used as a carrier for microbial inoculants in agricultural use, potentially replacing clay-mineral based carriers. This could be beneficial in ensuring a more homogenous mixture. An added benefit would be an otherwise "dry" mixture, which would turn to homogenous gel when water is added. For instance, silica gel tends to stay separate from the other constituents of the mixture and does not mix well. Biodegradability is of-course, a must have in soil environments.

Maybe this would give you some new ideas on possible applications.

Tanel

we can prepare biodegradable hydrogels. We do research on these hydrogels. Let me know if your are looking for biodegradable hydrogels. There are lot of biodegradable hydrogels which are in practice.

yes, I am looking for biodegradable Hydrogels.

Thank You Beenish and all

Hi Atul,

it depend on your purpose of using the biodegradable hydrogels. Biodegradable hydrogels will be completely degraded after a certain period of time base one the designed polymer structure. Basically, their persistent time ranges from day to several month. 

The benefice of biodegradable hydrogels in biomedical applications is that we don't have to remove the materials due to their completely degradation at the end.

Here are some example:

http://onlinelibrary.wiley.com/doi/10.1002/adhm.201500778/full 

http://pubs.rsc.org/en/content/articlehtml/2011/sm/c1sm05080j

http://pubs.rsc.org/en/content/articlehtml/2011/sm/c1sm05919j

https://scholar.google.com/citations?view_op=view_citation&hl=en&user=_v321s8AAAAJ&citation_for_view=_v321s8AAAAJ:IjCSPb-OGe4C

http://link.springer.com/article/10.1007/s13233-010-1002-2

Hope this helps.

Best,

Thanks u Cong Sir,

Definitely its going to help me.

Thanks u Cong Sir,

Definitely its going to help me.

Thank You Thambi Sir