Can the leader sequence be targeted for antiviral therapy (siRNA) against SARS-CoV-2?

More Talha Bin Emran's questions See All

What is impact of sampling frequency on deep learning?

Greetings, everyone. I am a bit curious to know how the sampling frequency of the device that captures the physiological signals impact the deep learning process. For example, if a device abc...

03 February 2021 379 4 View

IET Digital Library Access?

Hello to everyone, I do not have access to the IET Digital Library at the institution where I work. Can those who have access to this library send me the publication whose DOI is given below?...

13 January 2021 9,385 2 View

How can the moment tensor inversion results can present good waveform fit (synthetic and observed waveform) from generalized Cut and Paste scheme?

Depending upon the distance of the seismic station from the epicentre, the quality of waveform data and the improvisation of the synthetic waveform on it is often a question. If the Pnl waveform...

31 December 2020 6,602 2 View

Will the serum of healed patients can be considered to make a vaccine/drug against COVID-19?

22 December 2020 2,180 4 View

Are the receptor proteins on the surface of infected cells will increase or decrease the susceptibility of antivirals?

22 December 2020 3,242 4 View

Do you think the current COVID-19 vaccine would be effective against the new variant?

22 December 2020 5,025 9 View

Is it indispensable to receive a vaccine by the COVID-19 recovered person?

22 December 2020 5,883 5 View

Are COVID 19 vaccines reliable for people with medical conditions, like those with respiratory issues, diabetes, heart problems, etc.?

22 December 2020 5,948 7 View

Can HIV drugs will be a provisional or recurring option against COVID-19?

22 December 2020 7,872 2 View

What do you think the current COVID-19 vaccine would be effective against the new variant recently evolved in England?

22 December 2020 6,634 7 View

Which of the Covid-19 Vaccines would elicit the best immunoprotection and why?

I want to know which of the available Covid-19 Vaccines would elicit the best immunological response and why

02 March 2021 1,388 3 View

What SPSS analysis should I run with one IV (with two levels) and two DVs?

Hi, I am trying to figure out which test would be most appropriate to run for the following question: Is there a difference in task blood pressure between smokers and non-smokers? There are two...

01 March 2021 8,235 2 View

How vaccines of covid 19 work?

Millions ask how vaccines of covid 19 be successful and safe, its here to explain generally how vaccine of pfizer work ,mRNA vaccines teach our cells how to make a protein that will trigger an...

28 February 2021 2,723 4 View

Where can I find public datasets with Covid-19 patient information?

Hi, I'm looking for public datasets that have CT, X-ray information, or medical records for patients with Covid-19. Does anyone have suggestions?

28 February 2021 4,760 3 View

Is there any published or unpublished statistics on dropout rate (Dose1 to Dose-2) for Covid-19 vaccination in India, US, UK or any other country?

Are there any published or unpublished statistics or papers on the dropout rate (Dose1 to Dose-2) for Covid-19 vaccination in India, USA, UK, or any other country where vaccination has started at...

28 February 2021 4,237 1 View

If a given country passes mandatory 'vaccine passport rule' to go outdoors, otherwise stay at home, can it help to vaccinate all against COVID-19?

Wether vaccine passport declared not to go out of home without it may help taking COVID-19 vaccine. Can't it break individual's right to protect the community? Your comments on perspectives...

27 February 2021 5,549 23 View

How long do vaccines protect us against COVID 19?

Or will we have to get vaccinated every year, as in the case of influenza?

27 February 2021 1,048 5 View

Mediation path analysis - Can I run two seperate models?

I am wanting to run a serial mediation model with 2 x IVs, 2 x MVs, and 3 DPs (all continuous). Is it problematic to run 2 different models for each IV, keeping the MVs and DPs the same in each...

27 February 2021 5,681 3 View

SEM or Multiple Regression for an analysis without Latent Variables?

Hello, I have three hypothesis to test, all with the same IV. I am testing if the effect of the IV on the first DV is mediated by awe. I am then measuring whether the effect of the IV on a...

26 February 2021 8,399 5 View

Does RNAiMAX transfection reagent work in serum free medium?

I diluted siRNA and RNAiMAX in opti-MEM and added to the cells which they were in the growth medium. Is it a right way? or should I culture cells in the opti-MEM medium for a while and not in...

26 February 2021 10,041 3 View

Diwakar Bastihalli Tukaramrao

Leader sequences can be targeted as antivirals. In the case of influenza A virus, leader sequences contain signals for RNA replication, transcription and packaging. Though, SARS-COV-2 is different from influenza--it is imperative form classical approaches in case of HIV antivirals to target leader sequences could be an attractive strategy -- also because of the reason that, leader sequences may be conserved sequences and may be relatively easy to target in comparison to other regions that mutate constantly.

Also refer - Chapter Leader Sequence

Narjes Alfuraiji

Agree with @Diwakar Bastihalli

Gautam Bhardwaj

Yes possible in Japan scientists find out leader sequence. Then increase possiblity to prevent spread or treat