Can the leader sequence be targeted for antiviral therapy (siRNA) against SARS-CoV-2?

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Diwakar Bastihalli Tukaramrao

Leader sequences can be targeted as antivirals. In the case of influenza A virus, leader sequences contain signals for RNA replication, transcription and packaging. Though, SARS-COV-2 is different from influenza--it is imperative form classical approaches in case of HIV antivirals to target leader sequences could be an attractive strategy -- also because of the reason that, leader sequences may be conserved sequences and may be relatively easy to target in comparison to other regions that mutate constantly.

Also refer - Chapter Leader Sequence

Gautam Bhardwaj

Yes possible in Japan scientists find out leader sequence. Then increase possiblity to prevent spread or treat