since apomorphine is not availble, and pramipexole and apomorphine are both dopamine receptor agonists, so I'm wondering if I can use other dopamine receptor agonists to verify the rotation test of 6-OHDA induced PD mouse model.
In theory yes, but as far as I know, there is no injectable pramipexole available. Have you considered levodopa? This can also be injected in animals.
Peter Jenner’s article might be helpful, in particular informations provided in table 1.. Br J Pharmacol. 2011 Oct; 164(4): 1357–1391. doi: 10.1111/j.1476-5381.2011.01426.x Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease Susan Duty1 and Peter Jenner2 He recently had a talk about the prodyskinetic effet of short-term lasting ropinirole in mice(?).Unfortunaly, I do not remember the exact reference… Best regards Anatol Kivi
/LABORATORY ANIMALS: Acute Exposure/ A 0.1% injectable solution of pramipexole injected paravenously into the jugular vein was conditionally tolerated by rats. Single intravenous injections of pramipexole 0.1% solution into the marginal vein of the ear were tolerated by rabbits. Single intraarterial injections of pramipexole into the central artery of the ear were tolerated by rabbits. Health Canada; Product Monograph for Mirapex (Pramipexole Dihydrochloride) Tablets, Drug Identification Number (DIN): 02237145 p.41 (Date of Revision: November 27, 2012). Available from, as of June 12, 2015: http://webprod5.hc-sc.gc.ca/dpd-bdpp/start-debuter.do?lang=eng
Source: https://pubchem.ncbi.nlm.nih.gov/compound/Pramipexole#section=Non-Human-Toxicity-Excerpts
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