Adherence to frequent blood glucose testing by patients with diabetes via self monitoring of blood glucose assumed critical importance as it enables both patients and their physicians to have a view on blood glucose profile. This is of utmost importance in patients treated by insulin and/ or agents with hypoglycaemic potencies. However, many patients dislike frequent traumatic blood glucose testing and find it too uncomfortable and even painful. This is especially the case in children and adolescents. For this reason patients not infrequently deny testing which may adversely affect the management of diabetes. To overcome the problem of traumatic finger pricking to test blood glucose, several non-truamatic devices for self monitoring of blood glucose, totally avoid piercing the skin, have been discovered and marketed and found their way to practical use. Can painless methods for self monitoring of blood glucose increase the adherence of patients with diabetes to blood glucose testing?