I would love to hear your reactions to the following assertion:
The open science movement has some potential to reduce scientific misconduct.
Pre-registration might help some. Making research data more publicly available might help some. Any of the open science initiatives might help to some degree. But the problem of scientific misconduct is not going to be eliminated or even substantially reduced until the most powerful incentives supporting the behavior – including tenure, promotion, and grants – are revised to promote integrity as well as productivity.