MALDI mass spec is an excellent technique used to determine the mass of short biopolymers, such as single-stranded RNAs, but can the same technique be used to detect a non-covalently linked RNA duplex? That is to say, two fully complementary RNA strands are held together by hydrogen bonding alone. My prediction is that MALDI will be able to detect both strands separately, but not the duplex as one entire unit since they're not covalently linked. Any insight into this question will be most helpful.