I have prepared a polymer using cyclodxtrin as a crosslinker. After loading of a drug into cyclodextrin based polymer matrix, the drug showed enhanced drug release as compare to polymer without cyclodextrin. There are reports which describes that my model drug forms inclusion complex with cyclodextrin.
Dear Archana,
Basicly, you are right. The size of the drug is a strong point: e.g benzene or cyclohenane rings fit into the cavity of alpha- or beta cyclodextrin. Plese check the inclusiion with ROESY NMR spectroscopy
Kind regards
Helmut
yes according to argument we are following starch with high percentage of the amylose available in various grades so it form inclusion comples with cyclodextrin.literature also reveals use of caffeine with cyclodextrin and substituted cyclodextrin as more enticed examplee.
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