When using isoproterenol to induce myocardial infarction, one has to consider 2 different methods, namely by direct injection vs osmotic minipump implantation. Both methods are very easy to obtain but dosage will differ. The osmotic minipump method have successfully been done by Heather et al in 2009 and have made use of a much lower dosage for a longer period of time compared to an injectable dosage, which ultimaly are only injected for 2-3 days.

thank you very much for your reply.

NB. Isoproterenol injections is considered a "Heart Failure" model rather than a "Myocardial Ischemia" model, ie it causes heart failure by stressing the Beta -adrenergic system rather than damaging a portion of the heart with ischemia.

Isoprpterenol injections has been used as a model trial to induce cardiac failure in animals, mainly in dogs