I am working with a gastroretentive drug delivery system for a fixed combination product. Drug A has absorbance in 0.1 N HCl while drug B does not. Can I use two separate media for the fixed combination product, 0.1 N HCl for drug A and water for drug B?
Rahul Gupta
This condition generally arises if fixed dose combination consists of both weakly acidic and weakly basic compound. Now, here weakly basic dissolved in 0.1NHCL and weakly acidic in basic phosphate buffer. So during dissolution first 0.1NHCL should be used and then phosphate buffer (6.8/7.5). Finally, the calculation can be done by using simultaneous equation.
Equation for the simultaneous equation is very well written in Bentley and stenlake.
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