As I'm currently working on an antifibrotic drug and can't seem to find LX-2 cell lines or immortalized rat hepatic stellate cells (HSC-t6).
I think that you will find interesting the following article:
Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis
L Xu, A Y Hui, E Albanis, M J Arthur, S M O’Byrne, WS Blaner, P Mukherjee, S L Friedman, F J Eng
Gut 2005;54:142–151. doi: 10.1136/gut.2004.042127
You can use primary stellate cells, but take care with their activation, which is concomitant to the isolation procedure. Perhaps papers from S. Choi can help you.
They are an excellent model for study the efficacy of new anti-fibrosing agents and to know better the fibrogenesis process
I am looking for journals that admit the publication of results from applying the IUCN Standard for designing and monitoring Nature-based solutions. Many thanks for considering my request.
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