Hi! I have perform cylinder test in 6-OHDA animal model of PD to test the neuroprotective effect of one drug. I have obtained good results measuring the number of impaired forelimb wall contacts. Apart form this, I realize that there is a tendency in the time they spent in the cylinder until the 20 touches, being significantly less for the group tretated with the drug. That is why I was wondering if I can use thses results to explain the effect of the drug on the cognition and/or anxiety, as if I had done an open field, T-maze or elevated plus maze test.
Thank you in advanced!
Sara.
As long as you exactly explain what kind of apparatus in what circumstance, with what light and noise, which humidity and so on you can use the results. This does not exclude that the results from the cylinder test differ from the results from the open-field. The tests are not identical although they may point to the same direction.
Thank you for your answer Béatrice ;) Maybe I explained badly but I did not perform the open field test. That is why I was wondering if the results I obtained in the cylinder test are reliable enough to asses the potential anxiolitic effect of my drug.
I would say, cylinder test is mostly to check asymmetry and motor impairment. These differences could give an idea, that should be confirmed with other test
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