My di-phosphate salt compound contains two 3ry amino groups involved in salt formation and a one 2ry amine group that's not involved in salt formation. I wanna proceed N-Boc protection for this 2ry amino group; I'll proceed the reaction in water without using any bases.
Should I convert my compound to freebase first? or can I proceed it while in the salt form?
Abdulrahman
What is 3ry/2ry? tertiarally/secondary?
Sorry to ask?
I think you have to adjust the pH to basic by adding base if you want to do the reaction in water.
The best way maybe to do the reaction in anhydrous organic solvent with extra base(TEA or DIPEA), may need to convert the salt into free amine first.
I prefer to deal with free amines, convert to free amine then try to protect 2ry amine using 1:1 mole then check it's TLC , if their is more than one product separate by chromatography, after drying take IR, if the peak at around 3300 cm-1
disappeared and appearance of signals for Boc indicates the protection of 2ry amine
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