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Questions related from Abdulrahman Mahgoub
I have an allylic organic compound that I’ll be deprotonating to make an allylic anion. This anion will have the lone pair delocalizing on 2 different (chemically non equivalent) carbons. I’m...
04 July 2023 2,992 3 View
I want to do an alignment study for a ligand I have on an already published pharmacophore model by another group. Are there any available ways to import this pharmacophore model to Maestro to do...
01 January 2023 8,259 1 View
Why in HNMR the coupling constant of trans protons (typically ~17Hz) is higher than the cis protons (typically ~10Hz)? Also, why the antiperiplanar protons in a cyclohexane derivative have higher...
12 June 2020 4,921 4 View
Can I do heck coupling reaction on a compound in salt form without turning it into a free base? As for example doing Heck coupling on p-chloropyridiniumchlroide. I don't want to turn my compound...
20 April 2020 5,843 12 View
I'm trying to react Ar-CL compound (200mg) with a primary amine (1.2 equivalent), and I've found in the literature that they're using a very low amount of solvents (like 0.5ml) to proceed the...
18 March 2020 1,227 5 View
My di-phosphate salt compound contains two 3ry amino groups involved in salt formation and a one 2ry amine group that's not involved in salt formation. I wanna proceed N-Boc protection for this...
16 March 2020 1,158 3 View
Does the ester bond in my compound breaks If I proceeded a Sonogashira coupling reaction to react my compound (R-O-CO-Ar-Br) with the alkyne derivative? The reaction condition I'm...
18 February 2020 1,291 12 View
