Dear colleagues and professors.
I have synthesized new phosholipid polymer. This polymer has two terminal hydrophobic moities ( i.e. the carbon chain backbone and the tail in the monomer units), while the middle part in the monomer units is hydrophilic. We expected its solubility in water due to the hydrophilic part, but unfortunately it is not soluble in water and most organic solvents. It forms an emulsion in Methanol and only soluble in isopropanol and isopropanol -water (3:1) system.
I supposed to use these polymeric micelles for anticancer drug delivery.
Do you think it can work in some way and how can i use it as efficient drug carriers while it is not soluble in aquous media and most organic solvents.
Thank you.
Just wondering if you could mix another more amphiphilic polymer with this hydrophobic one, so the two of them might form some sort of self-assembly (micelles etc) and thus water-soluble.
Dear. Yang
Do u mean to prepare copolymer??
If so, i think it could be effective.
Dear Metwally:
I believe that the copolymer is difficult to create. This means that the need to significantly change the structure of your phospholipid. Consider increasing the hydrophilic amine functional group of the phospholipid.
Best regards.
so far you did not proved that polymeric micelles are formed under any conditions.
To act as vehicle for drug delivery you need to be able to form particles, droplets, vesicles or micelles compatible with body fluids including electrolyte.
Attach PEG moiety to your phospholipid...and tell me what is the CMC of your synthesized micelles After that I can tell what is next you should do..
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