Depends on the level of viremia (number of circulating mature viruses in the blood). Eclipse phase is essentially the period when the virus enters the cell before the production of proviruses. If we are talking solely about a virus in eclipse phase then no, since the virus is intracellular. but in the infected human body some viruses are intracellular and others are in the blood stream since there is a continues cycle of virus replication. I hope I understood your question correctly.
Thanks for your answer.. But there seems to be discordance between the viral secretions and blood viremia. This I extrapolated from the viremia and genital secretions among those maintained on HAART... I am just wondering since the HIV epidemics is largely driven by those with primary HIV infection.. And thus I wonder which stage of Fiebeg or eclipse period that drive this... Logically would be around the time when the viremia is at its zenith (set point) before it drops down
Ok I think I understood your question now. The risk of transmission is at its height after the eclipse phase, at this stage the infection is extremely localized to the exposure site, hence there is no "true" viremia, an the patient cannot transmit the infection. The eclipse phase takes approximately 7-12 days. Following this virus replication occurs, proviruses are produced and with the help of viral protease the virus buds extracellularly and disseminaties to lymphoid tissues and hence causes a viremia. It is at this stage that patients easily transmit the infection, this would be Fiebeg stages 1 and 2, typically after 12 days of the primary infection, it is when the most viral RNA can be detected in the circulation.
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