I'm looking to administer estriol over a long period of time (like more than a year). Multiple pellet implantations is not really feasible because it would be really bad for the mice. Also IP injections daily for more than a year would be tiring for me and stressful for the mice. So basically I'm curious if there is a way to continuously give the mice estriol through food or water.
Continuous administration through food or water is feasible and less-stressful, however, an accurate determination of how much drug really gets administered may be a challenge.
Another feature is oral bio-availability vs implant bio-availability of hormones.
It is nor recommended causes gastric ulcer and some metabolic disorders as well as hyper pleasia of mucosal layers
Estriol, a low potent hormone might not be effective when administered orally. Alternatively, it should be coated in pelletized feeds.
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