Can drug release be achieved for 24 hours and not for longer period of time with Polycaprolactone electrospinning, alone or in combination with any other polymer?as PCL is very slowly degrading polymer?
Hi Haroon, yes, you can do this. In fact, you can achieve almost instantaneous burst release of compounds from PCL fibers. It mostly depends upon the compatibility of your drug/solute within the PCL phase. If the PCL and drug have a poor affinity for one another (i.e., hydrophilic drug), then the drug will usually phase separate from the PCL, often coming to the surface of the fibers. In that case, if your release media wets out the fibers, release will occur rapidly as the drug dissolves off of the PCL fiber surface. You can try mixing various polymers with the PCL to modulate the release. I would also suggest trying various drug loading levels and spinning solvents. The devil is in the details.
Hi Haroon, yes, you can do this. In fact, you can achieve almost instantaneous burst release of compounds from PCL fibers. It mostly depends upon the compatibility of your drug/solute within the PCL phase. If the PCL and drug have a poor affinity for one another (i.e., hydrophilic drug), then the drug will usually phase separate from the PCL, often coming to the surface of the fibers. In that case, if your release media wets out the fibers, release will occur rapidly as the drug dissolves off of the PCL fiber surface. You can try mixing various polymers with the PCL to modulate the release. I would also suggest trying various drug loading levels and spinning solvents. The devil is in the details.
Drug release rate is a function of diffusion coeficient, distance to diffuse through, and polymer decomposition rate. For quick release You need short distance, high diffusion rate and high decomposition rate. In Your case the first is the most important, second deppends on the drug, third, if You have 24 h - forget about the third factor...
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