William, I agree the system is flexible, but with limits. The system is designed for organisms and not inert elements; for instance, calcium in ionic form not in free (inert) form. But even with free calcium our system can convert some of it into ionic form, but not overwhelmingly. The differences in the dead, sterile modern diet distorts both genetic orchestration and metabolic processes. I know what you mean relative to the advertising quality aspect as I feel there is a huge difference between what nature calls a nutrient (each with its own universe of co-factors and metabolic features)--i.e, Vitamin C is NOT ascorbic acid, but an immensely complex element that humans cannot manufacture as other mammals can. Too much of ascorbic acid causes our bodies to go into acisosis and all the chronic conditions that go with it. In organic form, however, (and this applies essentially to all nutrients), the body can regulate what is needed and what is not needed, making acidosis as a result of eating, say, too many oranges an impractical rather than health threatening matter. I am among those who considers both synthetic nutrition and natural crystalline nutrition as far inferior to organically bioavailable forms of nutrition. Hence, over-reliance of synthetic and natural crystalline in the short term may suffice in a nutrition crisis, but in the long term both variably will render consequences that a less than optimal to the body. Food, then, should be our main nutrition for optimal outcomes--and there there is much lattitude. In many cultures and climes diet can vary significantly and still be optimal. My contention in these times is that the US food supply has become less than optimal in micro and organic nutrients, and therefore, some supplementation may be needed. That supplementation will vary from person to person and is purely adjunctive to the person's diet, hydration, sleep, lifestyle, enviornmental challenges, mental-emtional, and physical exercise habits. So there is no misunderstanding, though, I feel certain that Michael Gonzeles and his associates have not conflict of interest in their endorsement of nutrition, and therefore are providing an hypothesis that is both observational and theoretical.

This is quite a complicate question and situation. Normally, deficiency in nutrition causes abnormal action of the organs in human and animals and even in plants and trees. For genetic factors , it is believed that they affect not only the physical but also the mental characteristics. In damaging the DNA, if it is possible, there should have more evident in individuals.

Yes, and thank you for your response, Nantakan. This question is a lot like getting homework we weren't expecting to get ourselves into (ha). I need to get a more direct Internet link to the article so that readers don't have to scroll the entire journal to find it. But I think once the discussion gets underway it will not be so complex. Thank you, again.

Maybe we need to discuss more on, why do "we need to abandon outdated paradigms of nutrient intake merely to prevent deficiencies" ? What this really means and what they are.

Yes, that would be a good place to start. I think what the authors mean there is this notion that RDA is enough for a population that has increasingly exposed to nutrient starved food and environmental stressors that have increased the need for a more optimal level of nutrition tailored to the individual and their genetics. They contend that there are three basci levels of nutrition need (poor, fair, and good), and that RDA measures tend only to bring most people into the fair category of nutrition, which in the long term brings disequilibrium and acceleration of degenerative diseases.

The authors also point out that between 1940 and 1991 there was a 76% reduction of trace minerals (the building blocks to cartilage, bone, etc.) in fruits and vegetables in the US and UK. That was in the days before GMOs, degermination, and irradiation really got underway. "This information makes the updated food pyramid not so much current as reflective of the need for an increase fruit and vegetables in order to get the same nutritional benefits. Americans on average do not even come close to the [under-estimated] recommendations..." They go on to state by not rectifying this in the public health of affected nations more than 100,000 deaths occur every year "due to medication properly prescribed and taken as directed" (this figure does not include the even greater number where these same medications cause deaths due to overdose and non-compliance, which arguably is skyrocketing today). In other words, we are eating more, but virtually starving for the nutrients needed to maintain optimum health, which in turn is overburdening an already over-wrought medical system in the affected countries. I note that my classes are always shocked when I reveal the cost in dollars and cents of all this. It is beyond comprehension for just about everyone.

Of course, fundamentally of course. Go figure!

Yes, it seems so self-evident, Marc. But to many we are still having to parse out the finer points of research and practical application to get it finally accepted in everyday practice. Thanks for joining the discussion.

It took millions of years for a human body to adapt to a way we are right now. According to Darwin's evolution theory, body changes and developments are based on necessity and external stimuli such as environment and types of food available. Just in few hundreds years we developed many kinds of artificial food. Let assume that a rate of change or adaptation of a human body is , let say, constant A, and a rate of change of foods and environment is , let say, constant B. By observation we know that A

Most interesting observations, Adam! Some of the mechanisms to which you referred is described in the Kreb's Cycle (see http://nutritionreview.org/2013/04/krebs-cycle-intermediates/). Thank you!

Dear Mr Max! You raised an interesting and important topic.

I'm not familiar with the works of Mr..Michael Gonzales,.but I think that ортомолекулярная medicine in combination with the traditional methods of treatment, was very useful. Most importantly, finding a competent specialist who will be able to choose the right elements. I think everybody knows that free radicals destroy the lipid membrane cells and causes damage to the DNA molecule.

In Russia and some other countries have developed methods of prophylaxis and treatment, which, probably, can also be attributed to orthomolecular medicine. Is the use of calcium phosphate drugs to prevent the disease Kashin-Beck , the iodization of products in areas where goiter, dental caries prevention substitution of sugar on the other sweet foods and water fluoridation. Not only vitamin C, but many other vitamins are considered from the point of view of orthomolecular medicine. First of all vitamins A, B1, B6, B12, E, and some others.

Biologically active substance, determine the atherogenic or antiatherogenic nature of the action diets. Оrthomolecular medicine should also include the use of plant sterols, fatty acids, multivitamin preparations, antioxidants and other substances for the prevention of atherosclerosis and increasing life expectancy. Of great importance antioxidants, especially natural, possessing a wide range of therapeutic and preventive actions

Since the beginning of 50-s N. Century Lazarev developed a direction for the use in medicine of purine and pyrimidine derivatives of a specific chemical structure, making related them with normal nitrogenous bases of DNA and RNA. Stimulating the synthesis of nucleic acids and proteins, these connections increased physiological and reparative regeneration, biological reactions and some other functions. The most known pyrimidine derivatives - methyluracil and pentauxil, which are applied for treatment of various forms of performance in leukopenia, wounds, burns; methyluracil is used for the treatment of stomach ulcer and duodenal ulcer.

There are various options for molecular interventions to improve the adaptive reactions of the organism in heart failure, and some other disorders. All they are connected with the influence on the synthesis of protein, nucleic acids and provision of energy of these processes. For these purposes it is supposed to use folic and orotovoy acids, vitamin B12, ATF, methionine, cysteine, glutathione and some other substances.

There are various options for molecular interventions to improve the adaptive reactions of the organism in heart failure, and some other disorders. All they are connected with the influence on the synthesis of protein, nucleic acids and provision of energy of these processes. For these purposes it is supposed to use folic and orotic acids, vitamin B12, ATF, methionine, cysteine, glutathione and some other substances .Оrthomolecular medicine is not something new in traditional medicine. Has long known fact that a deficiency of certain vitamins leads to the occurrence of specific diseases, on the other hand, in some diseases associated with metabolism introduction into the body of an appropriate nutrient leads to recovery (e.g., iron). However, оrthomolecular medicine looks much deeper than simply replacing iron deficiency anemia. With respect and wish all the best. Olga Shnaybel

Thank you for such a thorough and comprehensive treatment of the topic here, Olga! I tis good to see medicine in Russia is open to the orthomolecular principles as espoused by Pauling and others. We need more of this is American medicine today.

To make it easier for our commenters to get go the suggested article on "Metabolic Correction" I have modified the Question section to include this link for everyone: http://wakeupsense.com/Gonzalez-Metabolic-Correction.pdf. Thank you!

I think you are onto something here, John. We find many indiginous examples like you cited above. The status of mitochondrial DNA and its ability to manufacture ATP probably has more to do with the rest of the homeostasis factors that define the Kreb's cycle. We know that impaired mitochondria, for instance, changes everything that occurs in the body's ability to self-repair. I look at the Kreb's cycle in a macro and micro sense: micro at the currently recognized and demonstrated molecular level, but also at the more challenging to demonstrate macro level between the organs of the body. What does it take to keep the stomach acids at the right pH (1.0-2.5), for instance, and the release of the neurotransmitter to the pancreas when its time to secrete the bicarbonate into the duodenum (raising the pH to 8.5), which assists in opening the pyloric sphincter, followed by the upper intestine bicarbonate secretion (raising it to as high as 11.0-12.0!). The pH relationships of all of this and the bile that breaks down the fats is mind-boggling, but works when adequately aligned up and down the metabolic cascade.

Modern diets tend to interrupt all of this by huge quantities of sugared drinks washing down unchewed chyme sans one's saliva, which dilutes the stomach pH and prevents timely breakdown of the food into an adequate bolus and the plyoric sphincter will not open as often as it should. What I call in my lectures the "macro citric acid cycle" between the digestive organs breaks down, cholesterol is not broken down into smaller components, food to nutrition synthesis is haywire (which is the primary of the roles of serotonin, which we interrupte dramatically with SSRI/SNRI medications!), and we wonder why 90-100 million (or more!) Americans suffer from serious digestive orders. Perhaps there is more to the limited indiginous or aboriginal diets than meets the eye--perhaps the way it is eaten, how often, and the daily activities surrounding it without the stressors of modern society.

An interesting take, and I particularly liked the way Gonzales and his associates have approached the orthomolecular medicine theory to DNA repair. The ability to overcome some of the genetically programmed weaknesses in the population with nutritional corrections is something that we have seen on the front lines of health, but still needs more science behind it to bring the rest of th healthcare industry into line with the idea. Now, all this seems to be ignored and only the symptomatic results of underlying weaknesses garners our attention, as a rule.

John, thank you. I just noticed the error in the question which left out the words "be corrected" via Metabolic Correction--not sure how that happened, but do recall that there was a character limit that forced me to go in a few times to shorten the question, and somehow in the process those words were left off. Sorry. It was not a trick question (smile). But you did hit upon something important here in your C-diff example. We had one sent to us recently. All her nutrition was synthetic and inert and was causing problems. Recommendations were made to change of diet, weaning off meds that was causing an intractible case of candida (thrush etc.), and change of nutrition to enteric organic (not natural crystalline) form, and other therapies. In a short time, positive changes have been noted and C-diff appears to be resolving, as well. Of course, stomach acids nearly always decrease with age, hence, the addition of apple cidar vinegar--we prefer the capsule form as it seems to produce more protease enzymes with which to break down unburned proteins. Her accompanying GERD has reportedly stopped.

Thank you for contributing such insightful comments to the Question!

Dear Max Chartrand,

Thank you very much for your question.

Your question has a theoretical background and is aimed at formulation of practical prescription. Therefore, being busy in the last decade at an international congress in London, I didn’t want to give a hasty answer to it. You are right when writing that, according to the orthomolecular medicine approach, the so-called biologically-active food supplements and nutrients as such may be factors of the therapy and prophylaxis of some diseases. Therewith, "the right molecules should be used in the right amounts" (L. Pauling). We believe that the chemical compositions of the products that are introduced into living organisms are capable of stimulating the DNA changeability in the course of replication; however, the practical realization of prespecified DNA changes is problematic and, if possible, requires professional experience, keenness of observation, and discretion. In our work (Ostrovskii V.E., Kadyshevich E.A., Global J. of Science Frontier Research, 12 (6) version1.0 (2012) 1-36 (available in the ResearchGate), we consider briefly (pp. 27-29) and in a theoretical aspect the connections between the problems of DNA replication, optimal nutrition, and duration of life and arrive at definite conclusions. Therewith, we note that “we should caution the readers from premature applications of our conclusions and call to their careful and many-sided examination, although, the grounds of these conclusions are, apparently, sufficiently solid.”(p. 29).

Sincerely.

I agree with the prespecified DNA changes concept. Our clinic finds that an ATP stimulating therapy like deep cold laser (class 3b, Class 4) is needed in addition to the nutritional aspects--that nutrition by itself will likely do little in terms of DNA repair. Even then, it would be professional guesswork (going by health outcomes). Your comments are well taken.

Let me here try to (1) put a bit more precision in (a least a brief) statement of the metabolic correction hypothesis of Michael Gonzalez et al. to show that it is by no means trivial or transparent, and also to suggest some of the challenges it now does and will confront, closing nonetheless with an appreciation of the authors' contributions:

METABOLIC CORRECTION 101

Simplifying greatly, metabolic correction posits that metabolic harmony is requisite to optimal health, and that vitamins, minerals and nutrients in this context function as cofactors in the orchestration of enzymatically-driven biochemical reactions, and can be harnessed towards the improvement of cellular biochemistry to ultimately achieve metabolic/physiological optimization, primarily via the fact that increased concentrations of these agents fundamentally improve enzymatic/metabolic efficiency, which in turn may repair genetic and hereditary defects and disorders consequent to defective enzymes, allowing for:

(1) reduction of drug dosing/scheduling requirements,

(2) reduction of adverse events, and

(3) improvement of patient outcome.

This is intended only as a concise distillation, and readers would be well advised to pursue the full articles for detail.

CHALLENGES

Now, I will here present just four of several issues associated with the metabolic correction hypothesis, both because they reflect my concerns in the critical appraisal of any viable hypotheses, and also the stimulate further discussion:

1. Given that VM/nutrient concentrations, metabolism, and associated effects themselves exhibit wide individual variability as well as critical dependencies on multiple relatively uncontrollable internal and external factors and influences, including other coadministered nutraceuticals and individual dietary patterns - which to their credit the authors acknowledge - the consistency and sustainability of positive effects is not assured, and must be independently demonstrated rigorously, and in addition we do not currently have sufficient evidence and knowledge to wholly determine the achievement of the optimized metabolic efficiency state and its harmonic dynamics (see also below).

2. The metabolic correction and optimization needed and exerted for addressing one target condition may be in conflict with, or induce, potential collateral damage on other conditions that the same nutraceuticals can also influence. There is for instance some data that folate supplementation may be associated with increased mortality risk, although a dispositive conclusions awaits critical appraisal of the underlying studies, not yet systematically undertaken, made difficult by the fact that correlations between dietary folate intake and blood folate concentration vary from weak to moderate at best. In addition, the latest systematic review and meta-analysis (the Oslo SR/MA, Wien et al., BMJ Open 2012) of 10 RCTs on folate supplementation in the oncology context, finds for the six RCTs reporting prostate cancer incidence, an RR for prostate cancer of 1.24 for those receiving folic acid compared to controls, a clinically and statistically significant increase in prostate cancer after folic acid supplementation. This would represent unintended consequences if for instance we were using folate supplementation (alone or in the "Metanx" combination regimen) in the service of benefiting diabetic neuropathy (as the authors advocate in an associated article on metabolic correction for that condition target (these negative long-term findings are confirmative of the ProtecT Trial (Collin et al, Cancer Epidemiol Biomarkers Prev. 2010), as also suggested in the analysis of the Janus Cohort (de Vogel et al. Int. J. Epidemiol. 2013)).

3. Furthermore, long-term safety and exposure dynamics may be radically different, and adverse, from the main short-term effects examined in almost all studies. Consider the New Zealand meta-analysis (Fife et al., Colorectal Dis, 2011; independently critically appraised by me elsewhere) on folic acid supplementation on colorectal cancer risk: although there was no effect, positive or negative, up to 3-years, colonic surveillance beyond 3 years found increased risk of colorectal adenoma - and unfortunately, especially advanced adenoma - among the folate group, challenging contrary but weaker epidemiological findings claiming folate status is inversely related to the risk of developing colorectal cancer.

Similarly, I have argued independently based on robust data that that high omega-3 fatty acid consumption may exert clinically relevant adverse pharmacokinetic sequelae on the anti-HER2 biological agent's, lapatinib (Tykerb), metabolism in the oncology context (along with many other sobering cases).

3. Nutraceuticals may exert benefits beyond those exerted through enzymatic modulation and its consequences: there is data to suggest non-metabolic effects via both (1) inhibition or activation or modulation of underlying molecular pathways, as well as (2) epigenetic, not genetic, mechanisms, and these may more robustly be positively influenced by CAM agents outside the nutraceutical borders such as curcuminoids or AKBA/boswellic acids or natural HDAC/DNMT inhibitors.

IN GUARDED BUT REAL APPRECIATION

Nonetheless, there is much to be credited to Michael Gonzalez and co-investigators efforts:

(1) who have begun to systematically put the original perhaps overbroad precepts of orthomolecular medicine that too often argued beyond the boundaries of the evidence, onto a methodologically sounder foundation, accompanied with particular testable sub-hypotheses, and

(2) who have put forth in fact considerable plausible data - including I note, human clinical, not just preclinical, data - to support new precepts of the metabolic correction hypothesis at a more evidence-based level, and

(3) who by their highly articulated and often quite plausible and data-driven analyses are bound to stimulate pursuance of new directions in the scientific, not just anecdotal or speculative, study of the complex matrix of relationships between nutraceuticals - and their balance - and genetic factors and disorders long felt - incorrectly - to be the purview only of traditional pharmaceuticals, with a peripheral, cure-the-deficiency role assigned to vitamins, minerals and nutrients.

Thank you, Constantine, for a fine discussion on the metabolic correction topic. You are most correct that variables of time and controlling for confounds, as well as attribution as to results is a slippery slope when it comes to interpretation. And doubly so when applied to the rather myopic studies we see in pharmaceuticals, often taken so short term that it is through unfortunate patient experiences, collectively, before worse adverse effects become evidenced. Like you, I feel the principles they lay down present testable hypotheses that ought to be tested under scientific procedures, but yet they posit quite plausable conclusions. As you ably noted, titration and time need exploration for us to be sure, but the basic actions seem correct.

I always try to determine if we are talking of organic, bioavailable forms of nutrition or synthetics or crystalline natural. In our work here we find only the organic forms are dependable in producing repeated results, whereas the lesser forms of nutrition only superficially and with great variability from individual to individual provide consistent results. You mentioned the folate studies--synthetic or natural crystalline or organic? Perhaps the key in determining long term and consistent effects lie in the form of delivery.

Just some thoughts at random to your fine contribution, and thanking you for putting so much thought into it. Such insights cause us to stop and think more carefully.

Thank you all

Thank you all

I am here, at your leisure, remembered about another species of salt-Black (the Thursday) Black - so clean. In the old days it was the custom in Russia - making black salt. Salt fired in Russian furnace with the addition of leavened thick, cabbage leaves, rye flour Black salt is useful for people with kidney disease, heart disease, hypertension, hypotension. Because it is enriched with potassium, calcium, magnesium ions, and elements of selenium. Moreover, this salt is a great benefit as an adsorbent. Carbon contained in it in the form of finely porous charcoal, removes toxins from the body, that is, black salt is a "sink" of all the toxins. Its therapeutic effect is completely similar to the action of activated carbon.

Mount Athos tried to use the soaked rye bread. Cut the loaf and just tuck into a huge loaf of salt. Put in a Russian stove. Bread burns, and remains black salt. The mixture was then pulverized and sieved. Useful and tasty! All the best Olga Shn

This is great, Olga! We've been studying the trace minerals and other nutrients and benefits in Himalayan Salt and Real Salt, both of which appear to leave all commercial salts in the the proverbial dust. Now, we need to look at Black Russian Salt...looking for a source, do you have a suggestion?

From time to time, since the ethics code of DO NO HARM is an oft repeated refrain in medicine and health, we need ever to be as cognizant of another sage piece of immutable advice from the great Hippocrates: Let food be thy medicine and medicine thy food.

Absolutely true! More about salt. Black salt removes the burden from the liver and the digestive system in that it contains ten times less than ferrous metals, lead to violations of the kidneys, liver and digestive tract. It does not retain water in the body. Carbon in the form of finely porous carbon absorbent is therefore removes toxins. In medicine, black salt helps to relieve constipation, elimination of gas generation and increased appetite. Doctors recommend it for the prevention of mineral deficiencies. http://black-salt.ru/index.html And this is how it can be done-)! On Maundy Thursday Kvasny thick (after fermenting wort) mixed with a large rock salt. Instead, you can use thick leavened or Borodino rye bread (1 kg of salt - 5 kg of grain). Bread soaked with a salt mix is placed in a furnace or oven heated to 250 degrees, and to cook until the bread is not blacken. The resulting mixture was ground and winnow through a sieve. The remaining salt in a sieve and pour into jars used in place of common salt. Another option, I can send it to you. Good luck

Max:

Thanks for the feedback - shrewd and insightful as always - but here I would have to dispute that the results I cited are in any way dependent on the synthetic source of folates tested: in fact we know otherwise. Here's why:

There is some confusion I would suggest concerning whether organic-sourced nutrient content is significantly different from their synthetic-sourced comparables. Remember we are talking of the nutrient content and bioaccessibility of the elemental micronutrients including vitamins minerals, not of the nutritional benefit of the macro-foods themselves: it is well-established that consumption of organic foods may reduce exposure to pesticide residues and antibiotic-resistant bacteria, and hence serve a macro-nutrional benefit, but that is a different claim from any hypothesis that such organic foods as sources provide higher quality or bioaccessibility of component micronutrients like vitamin C, carotenoids, folates, etc. It is solely the later question I am addressing here, as the benefit in reduced exposure to pesticides, endocrine disruptors, contaminants, and antibiotics is not being disputed. But I would dispute that we have any robust, systematically reviewed and critically appraised evidence of any significant difference of micronutrient content and bioaccessibility between organic versus synthetic sourced micronutrients. Here's what we know, as I have systematically reviewed and critically appraised the data to date:

In the seminal systematic review from the UK Food Standards Agency (FSA) [1,2] of 162 relevant articles encompassing a total of 3558 comparisons of content of nutrients and other substances in organically and conventionally produced foodstuffs, of which 55 were appraised as meeting satisfactory methodological quality, no significant differences in nutrient and nutrient-related compound content between organically and conventionally produced crops were found for vitamin C, calcium, phosphorus, potassium, total soluble solids, titratable acidity, copper, iron, nitrates, manganese, ash, specific proteins, sodium, plant non-digestible carbohydrates, a-carotene and sulphur; the only significant difference being in nitrogen content which was higher in conventional crops, phosphorus and titratable acidity which were higher in organic crops.

This review has been predictably attacked by two NGOs, the Soil Association in the United Kingdom and the Organic Center in the United States, both heavily invested in the promotion of organic food. But the fraudulency of these attacks has been objectively and systematically reviewed and established by Joseph Rosen at the respected and independent Institute of Food Technologists [3] which found that much of the "proof" advanced by both these and related industry groups are based on non-peer reviewed studies (not reviewed by independent scientists) and on data that were in fact not statistically significant, along with nonexistent or incomplete data nevertheless “published” in the media. Similarly, if we look again at the nutrient level, polyphenol content and antioxidant capacity of apples grown under defined organic and conventional conditions were inappreciable and differences were predominantly due to variuability in climate, not nutrient content [4], with the same absence of significant difference in the content and bioaccessibility of carotenoids from organic and non-organic baby foods [5], and with absorption of folic acid and vitamin C not differing significantly between a synthetic and natural source [6], and so on for dozens of comparisons in other studies. (Bear in mind that a common polymorphism or variation in the MTHFR gene known as the C677T MTHFR polymorphism results in a less stable enzyme and plays an important role in maintaining the specific folate coenzyme required to form methionine from homocysteine, but there is no robust data to suggest that natural-sourced folate supplementation beyond minimal RDA are effective, nor even more effective, than synthetic-sourced folates in addressing this genetic contributant to folate quality and bioaccessibility).

Thus, at this time we can and should commit to organically-sourced macro-foods with intent towards reduction of harms from component pesticides, endocrine disruptors, contaminants, and antibiotics in non-organic macro-foods, but at the micronutrient level, the evidence fails to support any clinically relevant differences in quality or in bioaccessibility between organic-sourced versus synthetic-sourced micronutrients, including vitamins and minerals.

References

1. Dangour AD, Dodhia SK, … Uauy R. Nutritional quality of organic foods: a systematic review. Am J Clin Nutr 2009; 90(3):680-5.

2. Dangour AD, Lock K, … Uauy R. Nutrition-related health effects of organic foods: a systematic review. Am J Clin Nutr 2010; 92(1):203-10.

3. Rosen, J.D. (2010) A review of nutrition claims made by proponents of organic food. Comprehensive Reviews in Food Science and Food Safety 9, 270–277.

4. Stracke BA, Rüfer CE, … Watzl B. Three-year comparison of the polyphenol contents and antioxidant capacities in organically and conventionally produced apples ( Malus domestica Bork. Cultivar 'Golden Delicious'). J Agric Food Chem 2009 Jun 10; 57(11):4598-605.

5. Jiwan MA, Duane P, O'Sullivan L, O’Brien NM, Aherne SA. Content and bioaccessibility of carotenoids from organic and non-organic baby foods. J Food Composition Analysis 23(4), June 2010; 346–352.

6. Nelson EW, Streiff RR, Cerda JJ. Comparative bioavailability of folate and vitamin C from a synthetic and a natural source. Am J Clin Nutr 1975; 28(9):1014-9.

Thank you again, Constantine, a true scholar!

The debate over synthetic vs organic will go on forever, I'm afraid, because what we see in studies and what we see in patients tells us what you covered in your last paragraph, that we consistently see better outcomes in organically grown foods in patients healing from chronic conditions.

The micronutrients, including trace minerals, are a more difficult issue. We look at the trace minerals in Himalayan Salt and (Redmon) Real Salt vs common table sodium chloride and the differences are stark. In the former, patients with hypertension are able to eventually work their way off hypertensive meds, while with the latter we see a continuation of the problem with comparable intakes.

We also note that one reason the GMO vegetables and fruits gets short-shrift is because of the practice of pre-retail irradiation in the super market chains, whereas organically vegs and fruits are usually not irradiated. Certainly, they are not degerminated, meaning they can perpetuate the next generations of crop from the seed. For these and more reasons, we always advise organic over GMO where possible, realizing that in this day and age we must be pragmatic as to what is available in the marketplace. The only other answer is for all of us to start growing our own food perhaps (smile)?

Wow, John, phenomenal! Since moving to southern Arizona (to make our clinic more accessible to those coming in from all over the world) we left behind greenhouses, gardening, and a diet full of homegrown food. Down here we are determined to get back into the swing, but so far we keep bumping into the heat. So we will be putting in an elaborate greenhouse system in our backyard that cools in the summer and heats (slightly) in the winter. MIchigan is such a great garden state; many of our friends up there practically live off their land, bee hives and all!

Your comment on the garlic, yes, I don't have the data at finger tips either, but in the pre-Internet era I published several articles on garlic's (aged and raw) sulfanomides' properties vs Pharma's propensity to look for synthetic versions. I was invited to participate on one of those projects and was struck by the fact that nature can do almost anything better in that regard--the caveat being in delivery systems. Hence, delivery systems of the synthetics is far superior to most organic remedies (if not from whole food sources). But then, we have several examples of optimal delivery systems in organic (MCHC, for instance), so I think the key is that for therapeutic purposes there needs to be more reliable and bioavailable delivery systems (enteric, sublingual, etc.) if we want organic that is not delivered as whole foods to be on par with synthetics. Just some thoughts...

I am very interested in nutrition. I think one of the public health goals should be help people to become self-sufficient in terms of food, especially who lives in space constraints and urban spaces. This is also my personal goal.

By the way, Can I have access to these articles on garlic's ?

They were pre-Internet era, Mirella, and I don't even have them in my possession. But the immunological effects of garlic, especially aged garlic are legendary. In nature, immunological stimulation happens at much lower quantity levels than in synthetic forms, which was John's point. As a general rule large quantities of synthetics are best for acute changes, while organically available doses are better for chronic is our finding.

Thanks Max. I know that garlic is a good alternative for antibiotiques.

Tibetan means to cleanse the blood and blood vessels

This unique Tibetan homeopathic remedy to cleanse the heart, blood and blood vessels. Its effect is expressed as follows: washing out of the vessels ' plaque ' vehicle makes blood vessels young and flexible as a result of leaving diseases such as atherosclerosis, disappears likelihood of heart attack, stroke, leaving headaches , improves vision, decrease or disappear bulging veins in the legs . The body is completely rejuvenated.

Means should be prepared in the autumn, when only collected garlic , the last time you start taking money - end of January, when the garlic still in force. Later - is ineffective.

Preparation of Tibetan means to cleanse the blood and blood vessels

350 g of selected peeled garlic finely cut wooden pestle and grind in a clay slurry to cosude . Kashitsy wooden spoon to fold in a glass bowl , cover with a lid and a dark cloth - even " settles ". Then select the most liquid 200 g mass, pour it into another 0.5 liter jar and pour 200 g of pure rubbing alcohol ( substitutes totally unacceptable ) .

Cover tightly . Put in a cool place (not in the refrigerator) and cover with a black cap for ten days. After 10 days, squeeze through a dense mass of linen cloth wrung liquid put in a hood for 2 more days . After 2 days, the Tibetan means to cleanse the blood vessels and is ready for use. Make yourself a schedule of 10 days ' preparatory ' reception drops.

Days Breakfast Lunch Dinner

1st 1 2 3

2 nd 4 5 6

3rd 7 8 9

4th 10 11 12

5th 13 14 15

6th 15 14 13

7th 12 11 10

8th 9 8 7

9th 6 5 4

10 th 3 2 1

The rest of the liquid to drink 25 drops 3 times a day until it's drink. In the preparatory period necessarily write the numbers to avoid confusion. Any number of drops poured into 50 g of cold boiled milk.

Garlic drink on an empty stomach for 15-30 minutes (preferably 30 minutes) before a meal. If you go to work, dining dose take it with you. In the morning, a small bottle tightly sealable fill the dining dose - 50 grams of milk and a corresponding number of drops of garlic. Repeat the cleansing of the blood vessels and this Tibetan means in 3-6 years.

The second recipe Tibetan means to cleanse the blood vessels and 40 g of crushed garlic pour 100 g of alcohol or vodka , insist in a closed vessel. Take 10 drops 2-3 times a day 30 min before meal . To improve the taste you can add peppermint drops .

Tibetan tool can be used by sclerosis , anemia, flatulence, nephrolithiasis .

In atherosclerosis , high blood pressure , bronchitis garlic can be used as follows: peeled and chopped peel garlic cloves ( one head ) mixed with a glass of yogurt , to stand in for one night and the next day to drink brew for 2-3 times .

For the treatment of cardiovascular disease with atherosclerotic changes phytotherapists patients prescribed daily for 3 to 20 months consume garlic cloves (about 60 g), often in the form of an extract.

I wish you all good health

Olga, thanks for sharing this. Whereas the antibacterial properties of garlic are certainly not in dispute (it chases off the bacteria), the same might be a bit damaging to one's social life. I once had a friend who was a family counselor and used this exact mixture that you described and at times it was difficult for him to function in his role of counselor. Then, came out the so-called "odorless garlic"...well, I'm not so sure it was so odorless or that it worked as well as the real thing (ha).

Another note on a review I ran into on the subject of oxygen and cell entropy. http://www.cancerfightingstrategies.com/oxygen-and-cancer.html#sthash.9In7WcDW.dpbs.

I've not had a chance to analyze the claims of this item, but the items I read agreed with our findings at DigiCare Behavioral Research.

Dear Max! Good day! And about the garlic. If one clove swallow and drink water (in the morning)!! That will not be any smell. Proven on patients -)))

Thanks for the stuff! A lot of useful information. And about drinking hydrogen peroxide, just does not work. all the best

Dear Mr John! Yes, yes, I forgot to write that it should be cut About peroxide. There was a wave when many drinking water, hydrogen peroxide, the effects of all known. A garlic, it is unique! Sulfur, selenium, phosphorus, calcium, iron, chlorine, a small amount of iodine, quercetin, allicin and allesatin And pay attention to the link Doctors Max Chartrand Good luck

Here's another interesting information . Schuessler isolated and identified twelve mineral salts tissue , and concluded that the absence or deficiency of any of these salts leads to disruption of the cell metabolism or even loss of health. If the proper tissue salt regularly replenished in the form in which it can be assimilated by the cells , the cells are reduced ability to function normally , and the whole organism enters the self-healing.

Schüssler tissue salts are inorganic mineral substances and show its properties in the manufacture of their special homeopathic methods

@ Olga Shnaybel

very nice explanation cum information. Really, I am reading all these and also I like all these.

Thank you, Olga, for the kind comments. I wanted to share with everyone here something that we have been working with at our clinic. The variety of molds that are proliferating in the environment and the increasingly hypoxic state in which they are growing--might be useful to you in some way. The first one is a review study on the effects of hypoxia and growth of new species of aspergillus molds, the second is a practical application study suggesting hyperbaric oxygen and the third a simpler review on the topic:

http://www.ncbi.nlm.nih.gov/pubmed/7966201

http://www.medscape.com/viewarticle/432440

http://blackmold.awardspace.com/aspergillus.html

Dear Max! Thank you for your valuable information. Best regards. Olga

I can tell more generally (sorry for not being DNA-specific) that metabolic energy crisis is shown to be metabolically correctable. The Metabolism and Neuroprotection lab (Institut de Neurosciences des Systèmes, Marseille) showed that an energy substrate pyruvate (orally for 6 weeks) prevented development of neuronal pathologies in mice model of Alzheimer's in vitro and ex vivo.

http://energyforthebrain.com/recent-articles.html

In simple words, Biochemical alteration is resulted from the bad lifestyle (and it can be malnutrition, addiction or other bad practices). Though body tries to adapt in this situation but sometime it gets failed and outcome as alteration in biochemical level in the body. This can be corrected by doing good practices like yoga, aerobics, exercise, better daily routine and proper and hygienic food. As these practices switch the body into a state which it is designed for. Like aerobics and yoga increases the oxygen level in the body which provide more oxygenated blood to the tissues and decreases the anaerobic stress.

So finally good practices can do metabolic correction!!

Excellent points, Arvind. Key words are aerobics, oxygenization of blood (and cells), and decreased anaerobic stress.

Optimize health by improving enzyme efficiency, metabolism and physiology is the basis of metabolic correction. Short-term deficiencies of vitamins and minerals are common. The lack of needed micronutrients manifests insidiously and is difficult to identify. Most people function below 100% efficiency, they nevertheless do not present with any detectable disease or obvious symptoms. Some vague symptoms, such as lethargy, irritabil¬ity, insomnia and difficulty in concentrating, may be present but usually they are not taken seriously by the treating physician. Nutrient-related disorders are always treatable and deficiencies and insufficiencies are curable. Detecting and treating disease at its earliest stages of cellular biochemical abnormality, rather than waiting for clear clinical symptoms is cost effective and of benefit to the patient.

My point is the importance of early detection and correction of micronutrient deficiencies by the " first line"of physicians,those working at Primary Health Care Centers.In this way,the lab research on micronutrients can be applied in the field and help improve quality of life of the patients.Physicians have the duty to keep updating their knowledge and to practice an evidence based medicine.

(Michael J. Gonzalez, Jorge R. Miranda Massari. Metabolic Correction: A Functional Explanation of Orthomolecular Medicine. https://www.academia.edu/attachments/14472903/download_file)

Excellent observations, Clara and most insightful. You are most correct that humans operate with less than optimum levels of nutrition, the accumulation and prolongation of such eventually manifest into some form of "disease". I subscribe to recognizing subclinical forms of disease, which do no rise to clinical significance warranting medical care, but which--over long stretches of time--become serious impediments in human development. I would venture to say that most chronic conditions fall into the category of manifested (and often multiple) subclinical deficiencies and conditions. For instance, one who goes over the long term without sufficient sleep will one day find themselves with a chronic condition, perhaps psychologically and physically for which the answer is not a prescription medication, but...yes, sufficient sleep. The same could be said over chronic semi-dehyrdation--and deficiencies of nutrients, micronutrients, co-factors, etc...the restoration of which could bring restoration of health. I say "could" because there are usually multiple considerations required for restored health by the time a long term deficiency has taken its toll.

Yes, I totally agree; chronic conditions might be represented by the accumulation in time of multiple nutrient deficiencies. Identifying and correcting the deficiencies when they are still in subclinical stage would improve the general health status of individuals and, on a bigger scale, of populations. So, adequate strategies for prevention have to be addressed not only in research papers but practically in the medical field. Periodical lab tests targeted to identify the micronutrients deficiencies could be of real help. And when I say this, I'm thinking mainly to the very young people in schools, adolescents, who do not eat satisfactorily, either because of the predominance of unhealthy food in the markets or because of the lack of education on how to eat healthy. Accumulation of deficiencies starts from the young age and builds up over time leading to chronic diseases.

Many compelling and useful information. But I would like to remind about another possibly forgotten product, fish oil. Essential polyunsaturated fatty acids contained in fish oil , go to the body's prostaglandins - substances with anti-inflammatory action . In addition, they contribute to the proper absorption of fat by the body , expand the blood vessels that feed the heart muscle, reduce the formation of clots in blood vessels .

Recently, it was found that fish oil increases the content in the body of serotonin - the feel-good hormones ( helps combat depression ), reduces aggression, stress suppresses the secretion of hormones that cause spasm of blood vessels that feed the heart muscle and inhibits the processes of change in the brain , leading to loss memory and dementia.

Welcome back, Olga! Yes, the essential fatty acids of Omega-3 are most necessary. The problem that clouded this issue of late is the increase of commercially grown fish from which 90% or more of the EPA-DHA family is derived, and from the heated processing which destroys nearly all the echisonoids before consumers can consume it. It pays to be particular on the source of Omega-3. But you are so right, getting it to the consumer is the challenge, though.

Thank you. You, dear Doctor Max, right as always -)!! Of course the problem of ecology now urgently needed as ever. According to my childhood memories, my mom (doctor), poured in a tablespoon of fish oil gave black bread, and I'm a little salted fish oil that was delicious -)! I think the only thing for sure that you can not spoil or forge this mumie. At present biochemical shilajit composition : essential and nonessential amino acids (glutamic acid , glycine , histidine , phenylalanine , methionine , threonine , tryptophan , isoleucine , lysine , arginine , valine , aspartic acid, etc. ) , monounsaturated and polyunsaturated fatty acids ( oleic, petroselinic , linoleic , linolenic , etc.) , phospholipids , organic acids ( hippuric , benzoic , adipic , succinic , citric, oxalic, lichen , kojic , tartaric, and etc.) , essential oils , resins, resinous substances , steroids , alkaloids , enzymes , chlorophyll , tannins , coumarins , terpenoids , carotenoids (provitamin a) , flavonoids (including rutin ( vitamin E ) , vitamin B1 , B2, B3, B6, B12 , C, E, and 60 macro-and microelements (potassium , magnesium , calcium , sodium , phosphorus , manganese , iron , zinc , copper , sulfur , silicon, selenium, chromium, silver , cobalt , nickel, aluminum, etc. ) . In mineral composition mummie leading positions are occupied potassium, calcium, magnesium and manganese - the share of these macronutrients falls from 20 % to 60% of the inorganic component of the mummie ( mineral part mummie, consisting of free macro-and micronutrients , hydroxides and insoluble salts ( potassium carbonate , calcite , lime , dolomite, quartzite , etc.) is on average from 12 to 40 % of the mass of the useful natural product.)

The share of the organic part of the mummie , characterized by a high content of humic acids , more than 70% of the total weight of the mountain balm. Has a unique biochemical composition and a wide range of useful properties (immunomodulatory, regenerative, wound healing, anti-inflammatory, antibacterial, antiviral, antifungal, antiseptic, anticoagulant, detoxification, anti-inflammatory, analgesic choleretic, diuretic, antispasmodic, etc.

In humans, if we take as an example the Keshan disease associated with severe endemic selenium deficiency: fatal congestive cardiomyopathy. Keshan disease is endemic among women and children occurs in a geographical distribution covering localities northeast Ship to South-West China. This region is characterized by low availability of selenium in soils and agricultural products. In China, systematic dietary supplementation with sodium selenite was removed congestive cardiomyopathy usually fatal.

Therefore, the content of selenium in the blood comes from the food consumed. Selenium fixed in the active site of the enzyme glutathione peroxidase, superoxide dismutase associated with, catalase and the α-tocopherol, is a physiological defense system against oxidative damage caused by free radicals. Selenium is an antioxidant acting at the biological cell cytosol. Its action is supplemented by vitamins A and E act synergistically in the membranes of biological cells.

Studies already done on selenium shows that the highest concentrations found in fish. Maybe the faces of people who frequent the great restaurants in particular those providing fish meal like the businessmen for example is different from a simple worker

Excellent contribution, Benamar. Obviously, we have many deficiencies that bring chronic conditions, the solution of which is not more pharmaceuticals (which is what we see predominantly in the US) but more and better nutrition for the afflicted. Thank you again for your report.

Thanks, Olga, for such unique insights. And Merry Christmas/Happy Hannakuh/Whatever Your Season to you all!

Perfect source of selenium - seafood, particularly marine fish . In general, the mineral is mainly found in the protein product , especially in the liver , kidney , and in red meat .

Grains, seeds, nuts , too, can be a source of selenium , but when the soil in which they grew rich in this mineral . But check it out at home impossible. Therefore do not forget about mackerel , tuna and squid .

Vegetarians will not be superfluous selenium supplement in pill form. Experts recommend L- selemetionin . It is fully absorbed. One can also use the sodium selenate and - at a dose of 100 to 200 micrograms per day.

SUPER selenium LUNCH

That it contains the most adequate amounts of vitamins C and E for the most out of selenium :

squid salad with brown rice and onions

pickle with lamb kidneys ,

fish baked in foil , with a garnish of spicy greens and sweet peppers

rosehip infusion and a few walnuts. Dear Max! Thank you for the congratulations! I join and I wish you all good health, success in work and in the family.

Yes, and the B vitamins (organic from the food) to help the body to extract and assimimlate the iron, etc. needed for health. I've long been disappointed with the barbaric practice of today using elemental iron in high quantities to overcome anemia in females--the worst of all possible approaches, when the body already knows how to extract (second stage) iron from the food if the proper (organic) foods are eaten and metabolic correction considered. But, alas, much ignorance still pervades the field of health re nutrition and human health. Thank you again, Olga and everyone.

Kudos Dr. Max! A highly relevant discussion. I'm a sponge in your pond of knowledge. Sir Shares-a-lot! This message needs to get out there!

Stats 1-25-2014 14:00hrs EST - 8 / 0 · 59 Answers · 660 Views

1. I suggest sharing this query with your list of followers.

2. I suggest mixing up the topics up-top add/drop.

3. I suggest targeted "Share" with relevant RG members of high scores and cogent/articulate content.

RG Grad Program.

Thank you, Ravi. I appreciate the suggestions and the kind words. These are such important topics for discussion among those who can have input in health policy.

All my congratulations Max for the importance of the topic about nutrition and relevant as well as the participants in this debate answers.

Ravi, I am not sure how to get the tasks accomplished that you mentioned above (i.e., inviting others to participate in the question). I guess I've just not figured out all the navigating tricks of RG as yet (smile). Maybe you can help? Thank you for your kind words.

Dear Max

Why not ?

The word metabolism refers to how our bodies process the food we ingest to make the many chemicals we need to live. Our brains are uniquely sensitive to disturbances in this body chemistry. The brain needs amino acids to make and then break down neurotransmitters, and many specialized structural and catalytic proteins. Because of the brain’s specialized role in generating electrical impulses, it requires a flow of such ions as sodium, potassium, and calcium. It also needs lipids to form the myelin sheaths that insulate axons connecting cortical nerve cells with other parts of the nervous system.

Any disturbance in the brain’s chemical environment can lead to a metabolic disorder. Such a disease can take many forms. The lack of an enzyme or vitamin necessary for a specific chemical reaction in the body can cause a deficiency of an essential metabolic product (called a metabolite). That lack may impair brain development (as with cholesterol in Smith-Lemli-Opitz syndrome), cause seizures (as with copper in kinky hair disease), or have other harmful effects. Slowed chemical reactions can also cause the buildup of a compound that would otherwise be metabolized. The stored material may become toxic, as with lactic acid in the case of a mitochondrial disease, which in turn can lead to loss of nerve cells and breakdown of brain white matter. Some metabolic disorders produce mental retardation, cerebral palsy and seizures.

Metabolic dysfunction can also be the result of an external factor, such as a toxin or a nutritional deficiency. It can be the effect of disease in the liver, endocrine glands, or other organs. The fetal brain may be harmed by the mother’s alcohol abuse, thyroid deficiency, or phenylketonuria.

Source:

The Dana Foundation

http://www.dana.org/Publications/GuideDetails.

Max! I had to figure it out the hard way. Take advantage!

1. I suggest sharing this query with your list of followers. Right below your question there is a "Share" option. Click it! You'll see several options. Try them all until one slaps ya! :-)

2. I suggest mixing up the topics "up-top" add/drop. Same location under "Topics" Micronutrient deficiencies, Orthomolecular Therapy, Medicine, Biology, Social Science - Drop one and add another relevant topic occasionally with large follower list.

3. I suggest targeted "Share" with relevant RG members of high scores and cogent/articulate content. Find others from other discussions that had significant points of view (protagonists & antagonists alike) and share with them individually as you did with me. Simple!

Hope that helps you spread the word better.

[email protected]

http://www.flickr.com/photos/85210325@N04/12673410535/

'Can the micronutrients' deficiencies be corrected?'

Of they are, why not? There a few is needed: to find them all out in a given individual. That is the point.

Dear Prof Max, generally the main causes of disease are genetic, diet and nutrition, physical activity, and psychology. Some of them are out of our control such as genetic and psychology, while others we can control it. I think nutrition is the main and first cause for all diseases, I have one theory in my life that follow it daily: Good food in correct or right time. Majority of chronic diseases come from abnormal using of carbohydrate, sugar and oil, nowadays people rarely consume vegetables, fruit, milk, and white meat which are full of vitamins, minerals or even proteins. At the same time, most people not performing any physical activities such as normal walking, jogging, running or yoga. On the other hand, highest percentage of people depending on fast food, canned food, prepared food, frozen food or even dried food, which are all full of saturated oil, fat, additives, preservatives, unpermitted colors and flavours. These are all considered as the main causes of chronic diseases and cancer. TQVM

And what about (invisible) pollutants (e.g. contaminated food because of past/long-term exposure from radioactivity accidents in Chernobyl or Fukushima) absorbed by living beings and consumed by other living beings? I presume they might have long term consequences for exposed individuals, presumably also because they induce genetic mutations?

I agree wit Olga Shnaybel

I'm no expert in this field. But I can say the following. I Type II diabetes. I changed my diet. I accept simple food, vegetables and fruits. Former lifestyle. Result - sugar level down.

Specialists in quantitative genetics might say that for every phenotypic trait and its development there is a genetic (e.g. one or more genes and their interactions) and environmental (e.g. one or more environmental components) influence. Aging is not more than a development process influenced by genetic and environmental factors.

Hello Dr. Max and All,

This article from a few days ago points to for the first time a connection between environmental deficiencies/abundance (phenotype plasticity) and less/more reproductivity through identification of a common insulin signaling molecular pathway: http://news.harvard.edu/gazette/story/2014/03/key-connection/?utm_source=SilverpopMailing&utm_medium=email&utm_campaign=03.10.daily%201

The body has to have not just amino acid balance, but needs vitamin C and Vitamin B to help process it all correctly, but it is no good just making sure you get enough essential and non-essential amino acids and vitamins and minerals, if you are deficient in Nitrogen, as without Nitrogen your body will struggle to turn protein and fat into energy, the Nitrogen has to be perfectly balanced with amino acids vitamins and ionic minerals, sounds simple, but problem is everyone has different balance ratio, plus Gene mutations, that these compounds eg, are the key to opening the receptor subunit ion channel, and if the balance is wrong or you have a mutated gene, then amino acid proteins may convert and actually become something else entirely, so this needs to be research in a lot more depth yet. As we still don't really know what is a safe level of a single amino acid protein is actually safe yet, we just assume we do. I have been researching Florescence amino acid proteins, and their effects on REM sleep among other things at present, but what I have found interesting is the diets of Birds of prey, and how they convert amino acids into protein and pure energy, and how they unlike us are able to make their own Vitamin C source in their body, as they don't get it from any other source in their diet. For these birds it can be literally life and death if they don't get the correct balance of all in their diet, Calcium starts entering their blood stream as they struggle to filter it out due to Nitrogen deficiency and triggers disease and eventually death if not rectified. It is difficult to treat as symptoms don't show until problem has been going on a while. A similar thing seems to happen with some humans, even when they seem to be eating a healthy diet, testing PH levels like in plants can show up deficiency in some human diets but we also need to test Nitrogen levels as well, in a healthy person it is said they loss 40% of Nitrogen through excrement but in unhealthy

person eg not eating healthy, they only loss 20% of Nitrogen through excrement so it would seem the Nitrogen high content in this subpopulation is staying in the body for longer and casing health problems. Is the Nitrogen having an effect on Calcium production making higher amounts, and it is entering the blood stream or is it because of a lack of Calcium in their diet, causing the body to start stripping the Calcium straight from the bones to compensate and leaving Calcium deposits to travel round the body virtually un-noticed until disease sets in. Environmental factors are involved as well such as UV light and even Blue light from the Moon, and the heat and cold, and pollution, all have effects on amino acid conversion into proteins, also artificial light that mimic the natural day and night light also seem to have same effects on all this also.

Please check, "New Study Indicates DNA Can Be Altered Through Diet and Exercise "

http://www.naturalnews.com/024133_Chi_genes_health.html

Dietary improvements may help and may even reverse diseases in some cases. But not in all.

Natural medicine is definitely an area that needs exploring and more funding.

Iv´e never experienced that natural nutritions are missing micronutrientients. I´m afraid that here is talking pure commercial interest. I´m not talking about really sick people.

As well, this article demonstrates how such phenotype plasticity from resveratrol in some nuts, red wine and grapes reverses cell aging resultant from mounting diseases: http://hms.harvard.edu/news/genetics/new-reversible-cause-aging-12-19-13?

Autosomal Dominant gene mutations have to be passed to Child by both parents, but parents may only ever be carriers so will not show signs or symptoms of same disorder that can be triggered in their Child. Hundreds of todays diseases are linked to mineral deficiency, through balancing PH balance in body may help or stop disease from triggering. But naturally occurring ionic minerals can become toxic to anyone who may have a gene mutation, which leads to effects, on absorbing and transcription, expression and function, of whole body. If you then add the radiation effects, from Gamma radiation getting through holes we have discovered in our Ozone layer, that also effects all living cells and bacteria and even embryotic cells the 1st forms of life, can then be altered, by chemical instruction, if you have a gene mutation then, the ways amino acids naturally convert can be altered leading to a different DNA instruction being chemically given, than 1st intended. It is vital we learn what the correct balance is for everyone as we are all unique with different needs, like I said theory sound simple but putting in to practice for all living things very difficult, and would need vast amounts of data collection and compiling to move forward with this theory.

Definitely "malnutrition" is nightmare for some country's people as well as children too, we see pathetic conditions in some countries. God save them!!

Balanced diet is always required for good health. So the proverb developed "Health is Wealth". If parents have some problems they inherit to next generation too. We all know variety of diseases.

http://en.wikipedia.org/wiki/Malnutrition

http://www.hse.ie/eng/staff/PCRS/Online_Services/MUSTtool.pdf

I strongly believe that nutrition has a vital role on human's life. "You are what you eat" and supplement! Thinking just clinically I would say that the diagnosis and the prognosis of all kind of neoplasias pass trough a good evaluation of dietary conditions.

@Valcinir, no, really no. Most af the neoplasias are caused by chemical toxines, infections and radiation. It´s to easy to accuse the missing nutrition alone.

I agree nutrition can play and/or is playing and/or should play a bigger a role in medicine!

Period!

Nutrition, hydration, sleep, exercise, and sunlight are foundational to health. To ignore these is current medicine's big downfall. All the other assualts on human health, environmental etc. become much more problematic with the basics not in place. Prescription medications weaken the body's immunology when taken over the long term. Intelligently targeted nutrition do the opposite. The catalog of effects of missing nutrients, especially the micro nutrients and in their most organic and bioavailable form, is a catalog of a host of chronic conditions. If we want to see the state of human health change we will ernestly start with the basics.

I agree with Hanno that toxins from an overprocessed food supply, from public water supplies, and industry and transportation are causing a massive amount of illness and developmental delay in our population. Chronic and subclinical infections that bring a host of chronic disease including rheumatoid, CVD, and diabetic disease, happen as a result of a variety of causes, including neglected dental care, rampant prosthetic implantation, weakened immune systems from polypharmacy (a major problem for the US), and because we keep adding noxious chemicals to our water supply. These infections do not happen in a vacuum--nor are the natural state of the intricate human immune system. Healthy people just do not get these conditions. Add toxic levels of caffeine intake, chronic dehydration, and tobacco, etc. and it is no wonder chronic disesae of all kinds is exploding before our very eyes. The nations that do as we do in the US are starting to see the same disastrous results.

Valcinir reminds us of that which got Hippocrates, the "father of Western Medicine" thrown into prison for 20 years, for he said some pretty upsetting things like, "Let food be thy medicine, and thy medicine be thy food." He felt medical practice was too bullying and ignoring the body's natural ability to heal. Sound familiar? This dovetails with Hanno's comment about radiation exposure, the worst of which are the uncountable CT scans taken casually for just about any health question that arises today--becoming the number one cause of cancers like thyroid and no telling how many other cancers. One CT scan is equivalent to, what, 100 typical x-rays of radiation? In the growing and bottomless pit of government money now going into testing that subjects population to such risks of exposure we will find increases in the cancers these exposures cause. We are appalled that when we recommend a patient for a diagnosis on their condition how many come back with $30,000-$50,000 in testing done in a single or couple of days--scans that routinely reveal nothing, blood tests that say its all in their head, and a pile of prescriptions that will give them real disease in the end. Nothing is asked about their diet, nothing about their hydration intake, caffeine, how much sleep they get, what is happening in their lives at the time...of course, McMedicine in two minutes does not afford such salient information or even want to know it. It is instead interested in how much revenue can be milked from every referral and who's paying for it. Sounds cynical, but is the sad state of Western Medicine today--the more things change, even from the days of Hippocrates, the more they evolve into...the same thing. We need to get back to what got us here in the first place, and how best to shepherd the body back to good health.

Dr Max et al., what would be the organic sources of the trace elements like Mg, Zn, Mn, Cu, that are most easily available? Will eating a balanced diet, fresh fruits and vegetables (a big variety of greens) supply all of it, without need of over the counter vitamins?

Great contributions, Samantha and Jetty. Thank you!

Dear Colleagues: Thank you all for your interesting and enlighting comments. Special thanks to Max for bringing this important issue into a international discussion perspective.

Ironically the challenge in the "green areas" of the "malnutrition" map from Jetty is "obesity" and all the related ills of over nutrition (processed fats, carbs and proteins). The key in my un-schooled opinion is, the balance of micro-nutrients. As Miranda points out, these have to be compensated by well sourced OTC vitamin supplements. That would be "true health care" and not the "sickness care" offered by your hospital, doctor and health insurance company.

Ginger factoid: http://nutritiondata.self.com/facts/vegetables-and-vegetable-products/2447/2

I'm not a biochemist, but here is some information that may be inspired some ideas

PREVENTION

Selenium is antioxidant acting at the biological cell cytosol. Its action is supplemented by vitamins A and E act synergistically in the membranes of biological cells

Our work

Thyroid:

Blood Se concentration was found to be significantly lower in the Hyperthyroidism group than in the normal controls.

See article : S. Benamer, L. Aberkane et M.A. Benamar. "Study of blood selenium level in thyroid pathologies by INAA", Instrument Sciences & Technology 34:1-7, 2006

Psoriatic:

The lowering rate of Se concentrations in patients (general) versus controls. Applying the t-test for two groups gives a significant difference.

The lowering rate of Se concentrations in patients (male) versus controls. Applying the t-test for two groups gives a significant difference.

The lowering rate of Se concentrations in patients (female) versus controls. Applying the t-test for two groups gives a no significant difference.

Work submitted for publication 2014

IDEA

THERAPY (Cancer)

Comment that I added as a response to a shared question “Is there any attempt to model "Physics of Cancer"? by Paviz Parvin

1 - Among the eleven trace elements essential for humans, selenium is linked to genetique code, moreover, it is anti-oxidants, 2 - can be synthesized nanowires of selenium (eco-friendly) by bacteria 3 - see research if these nanowires can be used to fix, transport and the larger the drugs on cancerous cells , once identified without side effect (also review related genetic code, it is worth exploring)

@Ravi I did not follow your comment. Image taken from Wikipedia, link also provided they clearly mentioned "Percentage of population affected by under nutrition by country, according to United Nations statistics". Green areas are equal to

Yes Jetty! Good post! I was just pointing to the challenges that we in the "over nourished" societies ("green zone") face. For example, many bodies of water in NJ are forbidden for fishing to eat due to the toxic polutants in the waters from military and industrial activities. Only sport fishing. The toxins are more dilute in the ocean. So sea food is relatively safer, I suppose. Take for example of Ukraine and Kiev in particular. I see it falls in the "green" zone as well. I wouldn't want to consume nourishmet from there either. Sourcing of micronutrients is critical in its prescription for good health. How about Japan they seem to have a particular aversion to US beaf (and venison?) due to the scare of "mad cow" syndrome. What about the glowing sushi from Japan?:-)

My previous comment, the question on the understanding of the mechanism paliatif intake of trace elements?

What are trace element involved in the genetic code?

Plays there a role for cable transmission of information?

The immune system can be instructed to look for and recognize diseased cells?

OK now I got it, as you mentioned Obesity I was a bit confused.

If that is the case do you think sea food is safe!! Kindly do not think 100% sea food is safe recently I gave one presentation "Why do we farm salmon? Environmental, social and economical cost-benefits". I just give part of that (6 slides only) have look and especially last slide.

Ravi I agree your comments about the map.

Dhastagir! None of my doctors went into that much detail. Thanks for elevating my cognizance.

I suppose the use of statins for cholesterol, Actos for diabetes, Viox for RA, Claritin for allergy, Viagra for ED and other blood pressure control medication create similar effects as well, from my reading of other discussions. But none of my prescribing doctors warned me of their multitude of adverse effects. I just didn't like taking them due to their immediate side-effects that I felt. One exacerbated the other. These medications seem to work as a nice Pharma Team "helping each other along" and bringing you back to the doctor for more expensive tests rather than cure the cause. These are maintenance drugs not cures, ironically!

We advise all patients that are prescribed medications for long term chronic conditions to purchase a $39 Nurse Drug Handbook and to look up in detail the potential adverse reactions to medications they are prescribed and to discuss these with their doctor. If they experience any of the reported effects they should immediately report by telepphone or in person those effects so that a treatment modificaiton can be made. We also advise them to help their doctor determine what brought on the condition, as the cause more than likely is something over which they themselves have control, such as lifestyle, environmental exposures, diet, sleeping habits, hydration, high caffeine, tobacco, alcohol, narcotic pain killers, etc. These conditions do not happen in a vaccum--genetics may play into the picture, but usually mildly. In other words, just because many members of a given family experience x response to living near an iron smelter does not necessarily mean genetics are to blame. Just about anyone living near a minig smelter can expect x response in their health profile.