Is it possible that cyclic aromatic peptide self-assemble to form nanofiber? Due to pi pi interaction aromatic peptide form nanofiber, nanotube. But in cyclic form there is restriction in conformation. So is there any possibility to form fiber in cyclic form?
Try a larger cyclic structure which could ease out the strain more easily and may tend to produce the fiber. As you already know, the phenomenon is controlled by various factors in structure, the medium characteristics, and interaction including the polarity- try to manipulate these, if you can't change the structure! Nonetheless, the threshold size has to be present to form the final shape!
Thank you very much sir for your valuable answer. Actually my question is simpler. I have made a tetracyclic peptide containing aromatic residues. As it is already reported that phe-phe forms nanofibers, so whether the cyclic one also self-assemble to form nanofibers due to pi-pi interactions?
The simpler part of your question was not in black and white! The pi-pi interaction alone is not sufficient to lead to self fiber formation of the structure!
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