I wish I could explore this. Just a theory, a deduction that may give some explanation to COVID virulence. What is it, and how I came to it (Just an imagination) ?

First facts:

1) Hydroxychloroquine reduces the COVID viral shedding and may improve the disease severity. 2) Cytokine storm and ARDS are one of the main pathogenetic pathways leading to death.

Synthesis - hydroxychloroquine is used in autoimmune diseases, and cytokine storm is an exaggerated response to an antigen (a superantigen) - MAY COVID infection be a disrupted tolerance to a known antigen ??

Second facts:

1) Azithromycin reduces the viral shedding and may help the symptoms.

2) Diarrhea, Sore throat and Cough are part of the symptoms.

Synthesis - does COVID affect normal bacteria (such like streptococci) ?

Final theory: COVID affects human bacteria, changing pathogenicity and rupture of immune tolerance to a common human bacteria (such like strep), leading to exaggerated immune response and death.

Supporting parts:

- Transmission from animal to human may be more easy if the virus affects bacteria, rather than cells.

- Cadavers shed the virus. Cells are dead, but bacteria - alive.

- COVID sometimes affect myocardium. In rheumatic fever we also have myocardial damage.

Some other facts may support it, too, such like lack oh highly effective serology test, yet; sometimes biphasic nature of it; facts that children take it easier (view of higher level of tolerance, probably low level of life-time antibiotic exposure)