Traditional medicine often lacks molecular level understanding and clinical validation. On the other hand, modern drug discovery emphasizes target specificity, bioavailability, and molecular insights.
Biotransformationusing microbial, enzymatic, or plant cell systems to modify natural compounds, offers a promising bridge. By transforming traditional plant constituents into more potent, stable, or bioavailable derivatives, biotransformation can release novel bioactive metabolites, enhance drug-like properties and support the structure activity relationship (SAR) studies. This strategy aligns well with the demands of both evidence based medicine and natural product drug development.
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