There are some fecal and non-anaerobic cecal transplant studies I've read that have reported they were able to transfer donor's phenotype to recipients in rodent models. Since these studies were not done anaerobically, i assumed that most of the guts strict anaerobes died. Could this mean that the bacterial DNA "dead bacteria" could of had an impact on the host phenotype?
Hi
Can you attach articles that you read?
Probably their means were transplant of bacteria own, aerobic and non-aerobic, why receive DNA from outside is impossible in short time like a animal model study.
Hi Alireza,
Thank you for your response. I'm having trouble understanding how a host phenotype could be transferred by a gut microbiota transplant done under non-anaerobic conditions when a great deal of the bacteria within the gut are anaerobes. I would assume them to be dead and just leave the transfer of bacterial DNA. When performing sequencing techniques (e.g. next generation sequencing) on the recipients gut microbiota the donor's gut microbiota was successfully transferred into recipients, but this could be just the transfer of bacterial DNA.
I've attached a link to an article I read that did not collect their fecal contents under anaerobic conditions. Any explanation to this would be greatly appreciated.
Thanks,
https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-016-0851-z
they refer to this article
https://www.researchgate.net/profile/Wei_Jia21/publication/5803517_Inter-species_transplantation_of_gut_microbiota_from_human_to_pig/links/54f0d1f20cf2f9e34efd1bce.pdf
you can study it and figure out easily.
good luck.
Article Inter-species transplantation of gut microbiota from human to pig
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