Can anyone suggest me the chiral column for the resolution of racemic allylic alcohols?

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Matthew Bernart

As I recall a Pirkle-type chiral hplc column should work. Look that up and cyclodextrin column as well. Best luck!

William Letter

As I have separated these types of compounds many times in the past, I would not recommend any Pirkle or CD columns. They have poor selectivity. A good initial method would utilize a mobile phase of hexane and ethanol (or IPA) on a Chiralpak AD (or AD-H) column. Perhaps 50/50, 75/25 or 90/10 (Hex/IPA), all isocratic.

Mustafa Guzel

I also separated similar alcohols on AD and AD-H columns easliy with aforementioned mobile phase system. I would think 90/10 should give you the best resoulution. You can also try OD columns as well. Good luck..