First need to know which structure (or method ) of Au nanoXL AND
is polyclonal Ab a composite or really... Wait, I don't understand question.
Seems like the Au colloidal structure(s) generated would be determined by the method of its its generation.
Look up Au structures and their methods of synthesis.
the apices of the Au crystalline form(s) would determine, or categorize the clonal Ab form(s).
See
Dykman, L. and Khlebtsov, N. (2012) Gold Nanoparticles in Biomedical Applications: Recent Advances and Perspectives. Chemical Society Reviews, 41, 2256-2282. https://doi.org/10.1039/C1CS15166E
There are different methods, but I think using covalent binding is the best way. Three are free passive hydroxyl groups (OH) on surface of nanoparticles solution then you need to convert it to the active binding groups such as carboxyl group (COOH) first using chemicals such as citric acid and then latter by different types of covalent binding such as amide bond (EDC/NHS clic chemistry) make your attachment. Read below papers that explain the procedure in details. Good luck.
https://iopscience.iop.org/article/10.1088/0957-4484/27/10/105601/meta
Synthesis, characterization and in vitro evaluation of exquisite targeting SPIONs–PEG–HER in HER2+ human breast cancer cells
Article In vitro evaluation of actively targetable superparamagnetic...
In vitro evaluation of actively targetable superparamagnetic nanoparticles to the folate receptor positive cancer cells
https://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra14918a#!divAbstract
Synthesis, functionalization, characterization, and in vitroevaluation of robust pH-sensitive CFNs–PA–CaCO3
Article Synthesis and Characterization of Folate-decorated Cobalt Fe...
Synthesis and Characterization of Folate‐decorated Cobalt Ferrite Nanoparticles Coated with Poly(Ethylene Glycol) for Biomedical Applications
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