Dear Samuel,
The following papers discuss the topic of your concern:
1-Oral manifestations among patients with sickle cell disease
ARTICLE in INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 40(10):1146 · OCTOBER 2011
DOI: 10.1016/j.ijom.2011.07.406
https://www.researchgate.net/publication/255963266_Oral_manifestations_among_patients_with_sickle_cell_disease
ABSTRACT
Introduction: Sickle cell disease (SCD) is an autosomal recessive haemoglobinopathy. Although orofacial complications among SCD patients have been reported, their prevalence remains undefined. We therefore investigate the prevalence of jaw pain and lip numbness among SCD patients.
Methods: 495 patients with SCD were sent a questionnaire followed by a reminder. Those non-respondents were contacted by telephone.
Results: 173 (34.9%) completed our questionnaire with female to male ratio of 3:2, mean age of 36 years (3–76) and standard deviation of 15.4 years. The frequency of their attack varied widely from more than once a week to less than once every 6 months.
56 (32.4%) experienced facial or jaw pain. Of the 45 (26.0%) respondents who experienced sensory deficits to their lips, tongues or chins during a sickle cell crisis, 15% claimed to be permanent. Those patients who experienced jaw pain were more likely to have experienced sensory changes (Fisher's exact test, p = 0.0001). There was significant difference in the prevalence of jaw pain between the group with “crisis occurred once or more a month” and “crisis occurred less than once a month” (Fisher's exact test p = 0.0006) while sensory deficits were not statistically significant between the two groups (p = 0.368).
Conclusion: In our survey, jaw pain and perioral sensory deficits affected over 40% of SCD patients. Perioral sensory changes were more common in those who experienced jaw pain. The jaw pain was more prevalent in those with frequent sickle cell crisis.
2-Case Reports in Dentistry (see attached file).
Volume 2014 (2014), Article ID 413162, 5 pages
http://dx.doi.org/10.1155/2014/413162
Case Report
Numb Chin Syndrome as First Symptom of Diffuse Large B-Cell Lymphoma
Mario Carbone,1 Francesco Della Ferrera,1 Lucio Carbone,2 Gaia Gatti,3 andMarco Carrozzo4
1Department of Surgical Sciences, Oral Medicine Section, CIR Dental School, University of Turin, Via Nizza 230, 10126 Turin, Italy
2Private Practice, Turin, Italy
3Department of Medical Sciences, Section of Pathology, San Giovanni Battista Hospital, Strada Comunale di S. Vito Revigliasco 34, 10133 Torino, Italy
4Oral Medicine Department, Centre for Oral Health Research, Newcastle
University, Newcastle upon Tyne, Tyne and Wear NE1 7RU, UK
Received 1 November 2014; Accepted 2 December 2014; Published 16 December 2014
Academic Editor: Yuk-Kwan Chen
Copyright © 2014 Mario Carbone et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Numb chin syndrome is a rare sensory neuropathy of the mental nerve characterized by numbness, hypoesthesia, paraesthesia, and very rarely pain. Dental causes, especially iatrogenic ones, maxillofacial trauma, or malignant neoplasm are etiologic factors for this rare syndrome. Many malignant and metastatic neoplasms are causing this syndrome, like primary osteosarcoma, squamous cell carcinoma, and mandibular metastasis of primary carcinoma of breast, lung, thyroid, kidney, prostate, and nasopharynx. Haematological malignancies like acute lymphocytic leukaemia, Hodgkin and non-Hodgkin lymphoma, and myeloma can cause this neuropathy. The authors report a case of a 71-year-old woman in which the numb chin syndrome was the first symptom of the diffuse large B-cell lymphoma, which caused infiltration and reabsorption of the alveolar ridge and lower mandibular cortex. A biopsy of the mass was performed on fragments of tissue collected from the mandibular periosteum, medullary and cortical mandibular bone, and inferior alveolar nerve.
3-Proc (Bayl Univ Med Cent). 2012 Jul; 25(3): 243–245 (see attached file).
PMCID: PMC3377291
Numb chin syndrome as the initial presentation of posttransplant lymphoproliferative disorder
Rajin Shahriar, BS, Chris T. Alexander, MD, Cody R. Quirk, MD, Latoya Keglovits, MD, and Michael Van Vrancken, MD, MPH
Author information ► Copyright and License information ►
This article has been cited by other articles in PMC.
Numb chin syndrome is a sensory neuropathy caused by compromise of the mental nerve, the posterior branch of the inferior alveolar nerve, which leads to numbness or tingling in its respective distribution. There is no loss of motor function, as the inferior alveolar nerve contains no motor fibers. While associated with certain benign etiologies (1–3), the condition is increasingly reported as a manifestation of malignancy, including prostate adenocarcinoma (4, 5), lymphoma and leukemia (6–8), multiple myeloma (9), and breast cancer (10). While many of these malignancies are associated with other historical or physical signs or symptoms, numb chin often presents as the initial symptom (11–15), and awareness of this physical finding should raise suspicion for an underlying malignancy and may even contribute to earlier detection.
Hoping this will be helpful,
Rafik
Article Oral manifestations among patients with sickle cell disease
Dear Samuel,
The following papers discuss the topic of your concern:
1-Oral manifestations among patients with sickle cell disease
ARTICLE in INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 40(10):1146 · OCTOBER 2011
DOI: 10.1016/j.ijom.2011.07.406
https://www.researchgate.net/publication/255963266_Oral_manifestations_among_patients_with_sickle_cell_disease
ABSTRACT
Introduction: Sickle cell disease (SCD) is an autosomal recessive haemoglobinopathy. Although orofacial complications among SCD patients have been reported, their prevalence remains undefined. We therefore investigate the prevalence of jaw pain and lip numbness among SCD patients.
Methods: 495 patients with SCD were sent a questionnaire followed by a reminder. Those non-respondents were contacted by telephone.
Results: 173 (34.9%) completed our questionnaire with female to male ratio of 3:2, mean age of 36 years (3–76) and standard deviation of 15.4 years. The frequency of their attack varied widely from more than once a week to less than once every 6 months.
56 (32.4%) experienced facial or jaw pain. Of the 45 (26.0%) respondents who experienced sensory deficits to their lips, tongues or chins during a sickle cell crisis, 15% claimed to be permanent. Those patients who experienced jaw pain were more likely to have experienced sensory changes (Fisher's exact test, p = 0.0001). There was significant difference in the prevalence of jaw pain between the group with “crisis occurred once or more a month” and “crisis occurred less than once a month” (Fisher's exact test p = 0.0006) while sensory deficits were not statistically significant between the two groups (p = 0.368).
Conclusion: In our survey, jaw pain and perioral sensory deficits affected over 40% of SCD patients. Perioral sensory changes were more common in those who experienced jaw pain. The jaw pain was more prevalent in those with frequent sickle cell crisis.
2-Case Reports in Dentistry (see attached file).
Volume 2014 (2014), Article ID 413162, 5 pages
http://dx.doi.org/10.1155/2014/413162
Case Report
Numb Chin Syndrome as First Symptom of Diffuse Large B-Cell Lymphoma
Mario Carbone,1 Francesco Della Ferrera,1 Lucio Carbone,2 Gaia Gatti,3 andMarco Carrozzo4
1Department of Surgical Sciences, Oral Medicine Section, CIR Dental School, University of Turin, Via Nizza 230, 10126 Turin, Italy
2Private Practice, Turin, Italy
3Department of Medical Sciences, Section of Pathology, San Giovanni Battista Hospital, Strada Comunale di S. Vito Revigliasco 34, 10133 Torino, Italy
4Oral Medicine Department, Centre for Oral Health Research, Newcastle
University, Newcastle upon Tyne, Tyne and Wear NE1 7RU, UK
Received 1 November 2014; Accepted 2 December 2014; Published 16 December 2014
Academic Editor: Yuk-Kwan Chen
Copyright © 2014 Mario Carbone et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Numb chin syndrome is a rare sensory neuropathy of the mental nerve characterized by numbness, hypoesthesia, paraesthesia, and very rarely pain. Dental causes, especially iatrogenic ones, maxillofacial trauma, or malignant neoplasm are etiologic factors for this rare syndrome. Many malignant and metastatic neoplasms are causing this syndrome, like primary osteosarcoma, squamous cell carcinoma, and mandibular metastasis of primary carcinoma of breast, lung, thyroid, kidney, prostate, and nasopharynx. Haematological malignancies like acute lymphocytic leukaemia, Hodgkin and non-Hodgkin lymphoma, and myeloma can cause this neuropathy. The authors report a case of a 71-year-old woman in which the numb chin syndrome was the first symptom of the diffuse large B-cell lymphoma, which caused infiltration and reabsorption of the alveolar ridge and lower mandibular cortex. A biopsy of the mass was performed on fragments of tissue collected from the mandibular periosteum, medullary and cortical mandibular bone, and inferior alveolar nerve.
3-Proc (Bayl Univ Med Cent). 2012 Jul; 25(3): 243–245 (see attached file).
PMCID: PMC3377291
Numb chin syndrome as the initial presentation of posttransplant lymphoproliferative disorder
Rajin Shahriar, BS, Chris T. Alexander, MD, Cody R. Quirk, MD, Latoya Keglovits, MD, and Michael Van Vrancken, MD, MPH
Author information ► Copyright and License information ►
This article has been cited by other articles in PMC.
Numb chin syndrome is a sensory neuropathy caused by compromise of the mental nerve, the posterior branch of the inferior alveolar nerve, which leads to numbness or tingling in its respective distribution. There is no loss of motor function, as the inferior alveolar nerve contains no motor fibers. While associated with certain benign etiologies (1–3), the condition is increasingly reported as a manifestation of malignancy, including prostate adenocarcinoma (4, 5), lymphoma and leukemia (6–8), multiple myeloma (9), and breast cancer (10). While many of these malignancies are associated with other historical or physical signs or symptoms, numb chin often presents as the initial symptom (11–15), and awareness of this physical finding should raise suspicion for an underlying malignancy and may even contribute to earlier detection.
Hoping this will be helpful,
Rafik
Article Oral manifestations among patients with sickle cell disease
Please take a look at the following RG links and PDF attachments.
Article Prevalence of orofacial alterations in sickle cell disease: ...
Article Oral Changes in Patients with Sickle Cell Anemia of Dentistry Interest
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