What do you want to mensure, anit-stress behaviour, depression, proteins, neurotrofins?

you can do a mensure of melatonin, tyrosinase and other neurotransmitter.

Epinephrine, and norepinephrine are also part of the stress response. You should also consider some of the counter stress hormones as well, e.g. dopamine, serotonin, and oxytocin. The balance may be more important than the actual concentration.

You may also want to measure heart rate variability. This is a good indicator of stress. A ratio of stable rate to unstable rate over a 24 hour period may be a good indicator of how much stress is experienced each day.

Hi Velina,

I study chronic stress in rodent dams and offspring, but mostly focus on behavioral effects. Ecologically speaking, and intense stress will often result in decreased growth and/or a decrease in body weight. To some degree, we need to know what type of stress you are using and what the specific objectives are. In addition to cortisol (basal as well as stress induced levels), you could look at cort receptor methylation. Adrenal weights may change, but that is a somewhat crude measure that requires a robust stressor. In addition to the hormones mentioned previously, immune and growth factors (such as IL-6, TNF, BDNF and neurosteriods) are often altered by chronic stress. If you are looking at the brain, you could examine glial activity, neural connectivity, and gene expression/methylation of numerous factors in many different regions. As mentioned, heart rate variability is a good option as well, but this can be expensive if you require cardiovascular telemetry.

If you are working with rodents, you could evaluate their behavior in the forced swimming test. Chronic stress induces a passive behavior (floating) in the rodents and some treatments (substances, hormones, etc) reduce this passive coping.

With PHYSIONER, CODESNA provides the first simple and accurate measurement of physiological and emotional balance of a person and can continuously measure the benefits of an adequate response. This in a context to prevent risks of negative emotions or to follow-up a treatment.

Stress in itself is a natural and essential process to human living; however when it becomes chronic, stress can contribute significantly to malaises, to weaken the immune system and to the emergence of various diseases and disorders. This because, to cope with those stress agents, the body has established mechanisms that modify significantly its bio physiological balance. And all these mechanisms which, in the short term, allow the body to respond in an appropriate may, in the longer term, contribute to severe disorders: chronic stress, negative stress causing diseases known under the generic term “burnout».

CODESNA with PHYSIONER provides the first simple and accurate measurement of this imbalance and can continuously measure the benefits of an adequate response.

Real-time Stress Analysis

PHYSIONER, the real-time analysis solution to accurately measure physiological imbalances caused by chronic stress and negative residual malaise, which can cause a risk of burn-out.

This measure is executed in a simple and non-intrusive manner, by measuring the Heart Rate Variability of the person for 2 minutes with a specific respiratory protocol.

PHYSIONER is the first robust method, in real time and non-invasive for the measurement of physiological imbalance caused by chronic stress that is calculated on the sole measure of Heart Rate Variability (HRV).

From this simple physiological measure (heart rate taken for 2 minutes) our algorithms enables to measure and prevent the risk of “burn-out” and to have a reliable marker for a person’s well-being.

This product is intended for professional working on health and/or on well-being: osteopaths, sophrologists, psychotherapists, physicians, sports coach or well-being caches, etc.

The measurement of stress at your service

The value proposition is to improve the quality of the services you deliver to your patient / client by providing accurate measures on their physiological and emotional balance as well by monitoring over time those results.

Professional stress measurement

Companies concerned about the well-being of their employees can also benefit from the solution; they can set up a prevention protocol to detect negative stress and malaise created by a lack of motivation, and prevent psycho-social risks. Indeed, a study of Technologia estimated that more than 3 million employees in France have a high risk of burn-out.

I advice you to measure the plasma level of inflammatory signaling proteins