There are many opinions regarding which system is best in scoring CHB patients and plenty of studies in literature, none of which is conclusive about the superiority of one system over the other.
In my opinion it is best to adopt a score that fits the pathologist and physician's expertise. Based on my experience, using Ishak may provide a more specific indication in "borderline" patients given the wider range, but it depends largely on the kind of information you need.
http://www.ncbi.nlm.nih.gov/pubmed/12547412
If treatment decision is to be based on biopsy stage or follow uo biopsy is contemplated to check treatment results then Ishak modified HAI score may be slightly better. If it is purely for pathological purpose then any one of Scheur or METAVIR can serve the purpose because both are simple But the latter I feel is less rigorous in defining the points,
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