Hi, everybody. I am trying to design a hyperthermia induced drug release nano-system, containing a thermal-sensitive chemical linker which would be cleavage and release conjugated drugs after thermal treatment. It's best that this linker owns -NH2 ending.
However, i haven't found out an appropreate thermo-induced cleavaged linker between drugs and other polymers.
It seems azo linker is a candidate, which would release nirogen gas by cleavage in high temperature.
Please reccommand some text books or papers in terms of stimulus-induced cleavage of chemical bond, e.g. cleavage of disulfide linker in high inracellular glutathione (GSH) concentraion
Thank you every big man
I am not familiar with any relevant thermo-cleavable chemical bond for your application.
You might want to consider hydrophobic interactions, which can be tuned to be thermo-responsive. For instance, the tailoring of amphiphilic block copolymers has been explored in that endeavor.
You can find such information in Fleige et al. 2012 Adv. Drug Deliv. Rev.
http://dx.doi.org/10.1016/j.addr.2012.01.020
Thanks Fortier, but thermo-responsive polymer is not what i am looking for.
I am trying to design a triggered drug release from polymer by heat-stimu clevage of conjugated bond between drugs and polymer, not hydrophobic interation.
Anyway, thanks for your answer.
Yes, please find a relevant work that may be helpful to you.
http://www.ncbi.nlm.nih.gov/pubmed/22496064
thermo-sensitive polymeric micells are not i am looking for, but thank you a lot all the time.
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