Can anyone let me know the exact process and tentative time to infect Bronchitis in mice model ? I need to test a sample against mice model for bronchitis and for that purpose I want to have some bronchitis infected mice model. Which is the best way to have bronchitis infected mice model?
I have found that COPD (chronic obstructive pulmonary disease) can be infected by cigarette smoke. But whats the process for cigarette smoke and how many time it will need in this process ? Any other / best process if you can suggest it will be a great help. Thanks
Dear Rokib,
The following references and link describe the use of cigarette smoke to induce COPD (chronic obstructive pulmonary disease):
Stevenson C. S., Birrell M. A. Moving towards a new generation of animal models for asthma and COPD with improved clinical relevance. Pharmacol. Ther. 2011;130:93–105. [PubMed]
Vlahos R., Bozinovski S., Gualano R. C., Ernst M., Anderson G. P. Modelling COPD in mice. Pulm. Pharmacol. Ther. 2006;19:12–17. [PubMed]
Stevenson C. S., Belvisi M. G. Preclinical animal models of asthma and chronic obstructive pulmonary disease. Expert Rev. Respir. Med. 2008;2:631–643. [PubMed]
Churg A., Cosio M., Wright J. L. Mechanisms of cigarette smoke-induced COPD: insights from animal models. Am. J. Physiol. Lung Cell. Mol. Physiol. 2008;294:L612–L631. [PubMed]
Wright J. L., Cosio M., Churg A. Animal models of chronic obstructive pulmonary disease. Am. J. Physiol. Lung Cell. Mol. Physiol. 2008;295:L1–L15. [PMC free article] [PubMed]
Wright J. L., Churg A. Animal models of cigarette smoke-induced chronic obstructive pulmonary disease. Expert Rev. Respir. Med. 2010;4:723–734. [PubMed]
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878607/
Hoping this will be helpful,
Rafik
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