Mature RBC is enucleated cell, has ABO antigens which are genetically inherited, at which stage of RBC development (From erythroblast to mature RBC) it appears on RBC.
Immature erythroid cells express very little glycophorin. Instead, these cells express leukosialin, which is a major sialoglycoprotein in early erythroid cells that gradually decrease during the maturation of erythroid cells and is absent on mature erythrocytes.
Glycophorin appears at the pro-erythroblast stage and significantly increase during further maturation to erythroblasts. The amount of glycophorin apparently reaches a maximum before the reticulocyte stage.
A late stage marker on the other hand appears much later than glycophorin and appears only at the stage of basophilic erythroblasts. The level of this marker dramatically increases at the reticulocyte stage.
The amount of polylactosaminoglycan increases in parallel with that of the primer. Immature erythroid cells express a small amount of unbranched, linear polyactosaminoglycan (i), whereas more mature cells express large amounts of branched lactosaminoglycan (I). Thus, both the extension of the poly-N-acetyllactosamine and its branching increase during the maturation of the mature erythroid cells.
Consistent with the above conclusion, i-antigen is preferentially expressed on immature erthroblasts, while I-antigen is expressed on mature erythrocytes.
By cytochemical techniques, blood group A antigen can be detected later than the basophilic erythroblast stage.
Hi Chijioke
Thanks for valuable feed and interaction on the subject. I will correlate the facts and discuss further.
regards
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