The end product of complex coacervation depends on many parameters. It need not be spherical. If you need spherical particles have to use micronized form of drug in absence of surfactant. Surfactant will stabilise coacervate phase and may not coalesce on the drug particles. First try without drug and try to get spherical particles.

Mix gelatin and acacia at pH 7 and then reduce pH by adding acid. Observe under microscope frequently until you see a coacervation phase which looks like an emulsion. You will find spherical particles. Later try with drug.

Hi Hiep Ngyuen,

1) Why did you washed 2 times with 100ml distileed water?

2) And why washed with  25ml isopropanol and 25ml distilled water?