Water is crucial to human survival. Studies on surface water are well documented but precise knowledge of groundwater resources is difficult. Thus, accurate knowledge of groundwater resources could meet the necessities of water at present and in the long run. The application of the Analytic Hierarchy Process (AHP) and Geographical Information System (GIS) together with multi-criteria parameters has emerged as an efficient technique for delineation of groundwater potential in recent decades. Hence, in this study, the groundwater potential of Papumpare district of Arunachal Pradesh was delineated by combining AHP, GIS, and thirteen thematic layers (geomorphology, geology, slope, lineament density, drainage density, rainfall, distance from the major river, topographic wetness index, soil type, and land use/land cover) based on literature review and expert judgments.