I suggests animal tissue techniques. Humason G

https://www.biodiversitylibrary.org/bibliography/5890

thank you so much. Omar Hernando Avila-Poveda (Avila-Poveda OH) . This one seems informative.

Can you suggest some other book with rat histological sections especially of rat liver, brain and GI sections if you know any?

In theory Humason gives us the bases and foundation to develop histology in any tissue and any animal.

For something direct and specific I suggest you consult through SCOPUS or WoS.

with the keywords that you indicated.

I did the exercise and it shows more than 10,000 Scopus results, which is impossible to send here.

Give me your email and I will send you the search.

Cheers

Omar

Thank you @ Omar Hernando Avila-Poveda (Avila-Poveda OH).

My email address is

[email protected]

Anishma Karmacharya

I send the email containing several articles following the following keywords in SCOPUS. I hope you find these documents useful.

( TITLE-ABS-KEY ( rat ) ) AND ( ( ( ( ( ( ( histology ) ) AND ( pathology ) ) AND ( liver ) ) AND ( tissue ) ) AND ( brain ) ) AND ( gastrointestinal ) ) AND ( stain )

If you need other keywords, I can help you.

cheers,

Omar

Thank you. Omar Hernando Avila-Poveda (Avila-Poveda OH) . I don't use SCOPUS much but I will try searching via SCOPUS too from now on. he links seems very useful.

Once again thank you.

Hi Anishma Karmacharya,

Check these books:

- Chapter Liver

- Chapter Hepatobiliary System

- Chapter Gastrointestinal system

Good luck!

The problem is not the liver structure which is similar to humans, but how the rat liver will respond to your compound compared to humans and the experience that you have as clinical/experimental pathologist (it looks from your message that you are starting from scratch). It is not possible that you can have the same level of experience in liver, GI, and brain. Are three areas of different expertise which requires years of training in the clinical area. For the brain in particular, there is no atlas with cell identification and distribution available, in stark contrast with the clinical picture.

Especially if the study aims at translational applications, I would suggest that you confirm your results with a pathologist for each subspecialty in the academic center and ask also for suggestions. I have personal experience in many experimental papers in which the images do not match the findings described in plots, even if published in prestigious journals.

Thank you Giorgio Perino for the suggestion. That was what I wanted to ask people. Actually I have gone through histology books on rat. Those can be comparable for control groups of rats only but real problem is with the one fed with the target compound. As you mentioned, I barely can match my slides with the one from the published journals so little confused what to do. I agree about the experience we need to have perfect histological slides of rat sections since I am just a begginer. There is budget constrain too.. So affording a pathologist is hard. I will try to seek some help though. Thank you once again.

It is easy to afford a pathologist. You can write to me at any time or send me images for comments. I cannot cut the sections for you...All for free in the name of science.

Best,

Giorgio

Thank you Giorgio Perino . Thats so generous of you. I will try sending some of my slides later.

Anishma.